TY - JOUR
T1 - Neuroendocrine-immune Interface
T2 - Interactions of Two Complex Systems in Health and Disease
AU - Vela-Patiño, Sandra
AU - Salazar, Ma Isabel
AU - Remba-Shapiro, Ilan
AU - Peña-Martínez, Eduardo
AU - Silva-Roman, Gloria
AU - Andoneui-Elguera, Sergio
AU - Ordoñez-Garcia, Jose de Jesus
AU - Taniguchi-Ponciano, Keiko
AU - Bonifaz, Laura
AU - Aguilar-Flores, Cristina
AU - Marrero-Rodríguez, Daniel
AU - Mercado, Moises
N1 - Publisher Copyright:
© 2022
PY - 2022/4
Y1 - 2022/4
N2 - The relationship between the neuroendocrine and the immune systems is essential to maintain homeostasis. Their complex interactions are present in many physiological or pathological states whereby hormones exert different actions in immune system cells and vice versa. Hormones such as prolactin, growth hormone, cortisol and sex hormones are known to regulate the differentiation and function of immune system cells and the production of cytokines. Many of these cells express hormone receptors leading to the tempering of several autoimmune and neoplastic diseases. The pituitary gland is susceptible to autoimmune damage, be it because of primary lymphocytic hypophysitis, as part of IgG4-related disease or as an adverse event of treatment with immune checkpoint inhibitors (ICi). Finally, pituitary adenomas, like many other neoplasms, are frequently infiltrated by different cells of the immune system, a phenomenon that can be related to the degree of invasiveness of these lesions. The purpose of the present work is to critically analyze the neuroendocrine-immune interphase, from both a biological and a clinical perspective.
AB - The relationship between the neuroendocrine and the immune systems is essential to maintain homeostasis. Their complex interactions are present in many physiological or pathological states whereby hormones exert different actions in immune system cells and vice versa. Hormones such as prolactin, growth hormone, cortisol and sex hormones are known to regulate the differentiation and function of immune system cells and the production of cytokines. Many of these cells express hormone receptors leading to the tempering of several autoimmune and neoplastic diseases. The pituitary gland is susceptible to autoimmune damage, be it because of primary lymphocytic hypophysitis, as part of IgG4-related disease or as an adverse event of treatment with immune checkpoint inhibitors (ICi). Finally, pituitary adenomas, like many other neoplasms, are frequently infiltrated by different cells of the immune system, a phenomenon that can be related to the degree of invasiveness of these lesions. The purpose of the present work is to critically analyze the neuroendocrine-immune interphase, from both a biological and a clinical perspective.
KW - Hypophysitis
KW - Immune check point inhibitors
KW - Immune system
KW - Neuroendocrine system
KW - Pituitary
KW - Tumor-infiltrating lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=85124414224&partnerID=8YFLogxK
U2 - 10.1016/j.arcmed.2022.01.003
DO - 10.1016/j.arcmed.2022.01.003
M3 - Artículo de revisión
C2 - 35153080
AN - SCOPUS:85124414224
SN - 0188-4409
VL - 53
SP - 240
EP - 251
JO - Archives of Medical Research
JF - Archives of Medical Research
IS - 3
ER -