TY - JOUR
T1 - Modulating the expression of genes associated with hepatic lipid metabolism, lipoperoxidation and inflammation by cocoa, cocoa extract and cocoa flavanols related to hepatic steatosis induced by a hypercaloric diet
AU - Rabadán-Chávez, Griselda M.
AU - Miliar Garcia, Angel
AU - Paniagua Castro, Norma
AU - Escalona Cardoso, Gerardo
AU - Quevedo-Corona, Lucia
AU - Reyes-Maldonado, Elba
AU - Jaramillo-Flores, María Eugenia
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Cocoa and its bioactive compounds are widely known for its beneficial effects as attenuate insulin resistance, hepatic lipid deposition, inflammation and oxidative stress induced by hypercaloric diets. The present in vivo study investigated the effects of cocoa powder, cocoa extract and its main flavanols (epicatechin, catechin and procyanidin B2) on the expression of genes involved in the regulation of hepatic lipid metabolism, lipoperoxidation and inflammation associated to hepatic steatosis induced by a hypercaloric diet. This study demonstrates that oral treatment with cocoa powder, cocoa extract and cocoa flavanols significantly attenuate hepatic steatosis induced by hypercaloric feeding, in part, through downregulation of genes involved in hepatic fatty acid uptake (PPARγ, CD36) and lipogenesis (ACC) and upregulation of key regulators of mitochondrial function (PPARα, SIRT1) and FA oxidation (PGC-1α) as well as in attenuating hepatic oxidative stress and inflammation by upregulating hepatic antioxidant enzymes and decreasing gene expression of proinflammatory cytokines (TNF-α, IL-6).
AB - Cocoa and its bioactive compounds are widely known for its beneficial effects as attenuate insulin resistance, hepatic lipid deposition, inflammation and oxidative stress induced by hypercaloric diets. The present in vivo study investigated the effects of cocoa powder, cocoa extract and its main flavanols (epicatechin, catechin and procyanidin B2) on the expression of genes involved in the regulation of hepatic lipid metabolism, lipoperoxidation and inflammation associated to hepatic steatosis induced by a hypercaloric diet. This study demonstrates that oral treatment with cocoa powder, cocoa extract and cocoa flavanols significantly attenuate hepatic steatosis induced by hypercaloric feeding, in part, through downregulation of genes involved in hepatic fatty acid uptake (PPARγ, CD36) and lipogenesis (ACC) and upregulation of key regulators of mitochondrial function (PPARα, SIRT1) and FA oxidation (PGC-1α) as well as in attenuating hepatic oxidative stress and inflammation by upregulating hepatic antioxidant enzymes and decreasing gene expression of proinflammatory cytokines (TNF-α, IL-6).
KW - Cocoa
KW - flavanols
KW - gene expression
KW - hepatic lipid metabolism
KW - inflammation
KW - lipogenesis
KW - proinflammatory cytokines
UR - http://www.scopus.com/inward/record.url?scp=84960977049&partnerID=8YFLogxK
U2 - 10.1016/j.foodres.2016.03.019
DO - 10.1016/j.foodres.2016.03.019
M3 - Artículo
SN - 0963-9969
VL - 89
SP - 937
EP - 945
JO - Food Research International
JF - Food Research International
ER -