TY - JOUR
T1 - Microbial paclitaxel
T2 - Advances and perspectives
AU - Flores-Bustamante, Zoila R.
AU - Rivera-Ordũa, Flor N.
AU - Martínez-Cárdenas, Anahí
AU - Flores-Cotera, Luis B.
N1 - Funding Information:
We want to express our appreciation to Dr Demain for his stimulating and outstanding scientific contributions, and for his kindness and human qualities. Also, we thank the editors of this special issue for inviting us to participate in celebrating Dr Demain’s 60 years of distinguished career as scientist and educator. Funding was provided by Semarnat-Conacyt (Project 0368), Fomix-Conacyt-Hidalgo (project 2006-01-49004) and ICyTDF (project PIFUTP08-90). AM-C received grant-aided support from CONACYT.
PY - 2010/8
Y1 - 2010/8
N2 - Paclitaxel is a potent and widely used antitumor agent. Considerable worldwide research efforts have been carried out on different production alternatives. Since the description of the first paclitaxel-producing fungi, more than 15 years ago, microorganisms have been investigated as potential alternatives for an environmentally acceptable, relatively simple and inexpensive method to produce paclitaxel. However, in spite of significant research on paclitaxel-producing microorganisms, no commercial fermentation process has been implemented up to now. The aim of this study is to review the present status of research on paclitaxel-producing microorganisms and the ongoing efforts to develop heterologous paclitaxel biosynthesis, and analyze the perspectives of microbial fermentation for paclitaxel production.
AB - Paclitaxel is a potent and widely used antitumor agent. Considerable worldwide research efforts have been carried out on different production alternatives. Since the description of the first paclitaxel-producing fungi, more than 15 years ago, microorganisms have been investigated as potential alternatives for an environmentally acceptable, relatively simple and inexpensive method to produce paclitaxel. However, in spite of significant research on paclitaxel-producing microorganisms, no commercial fermentation process has been implemented up to now. The aim of this study is to review the present status of research on paclitaxel-producing microorganisms and the ongoing efforts to develop heterologous paclitaxel biosynthesis, and analyze the perspectives of microbial fermentation for paclitaxel production.
KW - HPLC-MS
KW - bacteria
KW - fungi
KW - genes
KW - taxol
UR - http://www.scopus.com/inward/record.url?scp=77956248163&partnerID=8YFLogxK
U2 - 10.1038/ja.2010.83
DO - 10.1038/ja.2010.83
M3 - Artículo de revisión
SN - 0021-8820
VL - 63
SP - 460
EP - 467
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 8
ER -