TY - JOUR
T1 - MetastamiRs
T2 - Non-coding microRNAs driving cancer invasion and metastasis
AU - Lopez-Camarillo, Cesar
AU - Marchat, Laurence A.
AU - Arechaga-Ocampo, Elena
AU - Perez-Plasencia, Carlos
AU - del Oral-Hernandez, Oscar
AU - Castaneda-Ortiz, Elizabeth J.
AU - Rodriguez-Cuevas, Sergio
PY - 2012/2
Y1 - 2012/2
N2 - MicroRNAs (miRNAs) are small non-coding RNAs of ~22 nucleotides that function as negative regulators of gene expression by either inhibiting translation or inducing deadenylation-dependent degradation of target transcripts. Notably, deregulation of miRNAs expression is associated with the initiation and progression of human cancers where they act as oncogenes or tumor suppressors contributing to tumorigenesis. Abnormal miRNA expression may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic targets in cancer. Recently, several miRNAs have been shown to initiate invasion and metastasis by targeting multiple proteins that are major players in these cellular events, thus they have been denominated as metastamiRs. Here, we present a review of the current knowledge of miRNAs in cancer with a special focus on metastamiRs. In addition we discuss their potential use as novel specific markers for cancer progression.
AB - MicroRNAs (miRNAs) are small non-coding RNAs of ~22 nucleotides that function as negative regulators of gene expression by either inhibiting translation or inducing deadenylation-dependent degradation of target transcripts. Notably, deregulation of miRNAs expression is associated with the initiation and progression of human cancers where they act as oncogenes or tumor suppressors contributing to tumorigenesis. Abnormal miRNA expression may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic targets in cancer. Recently, several miRNAs have been shown to initiate invasion and metastasis by targeting multiple proteins that are major players in these cellular events, thus they have been denominated as metastamiRs. Here, we present a review of the current knowledge of miRNAs in cancer with a special focus on metastamiRs. In addition we discuss their potential use as novel specific markers for cancer progression.
KW - Cancer
KW - Epithelial-mesenchymal transition
KW - Invasion
KW - MetastamiRs
KW - Metastasis
KW - MicroRNA
UR - http://www.scopus.com/inward/record.url?scp=84857672136&partnerID=8YFLogxK
U2 - 10.3390/ijms13021347
DO - 10.3390/ijms13021347
M3 - Artículo de revisión
C2 - 22408395
SN - 1661-6596
VL - 13
SP - 1347
EP - 1379
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 2
ER -