TY - JOUR
T1 - Mesquite leaves (Prosopis laevigata), a natural resource with antioxidant capacity and cardioprotection potential
AU - García-Andrade, M.
AU - González-Laredo, R. F.
AU - Rocha-Guzmán, N. E.
AU - Gallegos-Infante, J. A.
AU - Rosales-Castro, M.
AU - Medina-Torres, L.
N1 - Funding Information:
The valuable assistance of Socorro and Martha González-Elizondo from CIIDIR-IPN Unidad Durango in sample identification is fully appreciated. Author MGA acknowledges graduate scholarship from CONACYT (Mexican Council of Science & Technology) . The present work was partially supported by SEP-DGEST .
PY - 2013/1
Y1 - 2013/1
N2 - The antioxidant activity of acetone extracts and purified fractions from Prosopis laevigata leaves were evaluated as well its cardioprotection potential in vitro. Mezquite leaves were dewaxed with petroleum ether and extracted with aqueous acetone (70%); the polar extract was purified in Sep-Pak® Cartridges and their fractions evaluated. Significant differences among fractions and crude extracts were found in total phenolic content (Folin Ciocalteu), antioxidant capacity by scavenging hydroxyl and DPPH radical assays. Purified fractions showed antihypertensive effects inhibiting angiotensin converting enzyme and cardioprotection inhibiting low density lipoprotein oxidation. The HPLC profile displayed phenolic compounds such as gallic acid, catechin, gallocatechin, epicatechin gallate, rutin, and luteolin that may explain these antioxidant and biological properties. Mesquite leaves can be a source of bioactive phenolics as nutraceutical ingredients.
AB - The antioxidant activity of acetone extracts and purified fractions from Prosopis laevigata leaves were evaluated as well its cardioprotection potential in vitro. Mezquite leaves were dewaxed with petroleum ether and extracted with aqueous acetone (70%); the polar extract was purified in Sep-Pak® Cartridges and their fractions evaluated. Significant differences among fractions and crude extracts were found in total phenolic content (Folin Ciocalteu), antioxidant capacity by scavenging hydroxyl and DPPH radical assays. Purified fractions showed antihypertensive effects inhibiting angiotensin converting enzyme and cardioprotection inhibiting low density lipoprotein oxidation. The HPLC profile displayed phenolic compounds such as gallic acid, catechin, gallocatechin, epicatechin gallate, rutin, and luteolin that may explain these antioxidant and biological properties. Mesquite leaves can be a source of bioactive phenolics as nutraceutical ingredients.
KW - Antioxidant
KW - Cardioprotection
KW - Mesquite
KW - Polyphenols
KW - Prosopis
UR - http://www.scopus.com/inward/record.url?scp=84871428112&partnerID=8YFLogxK
U2 - 10.1016/j.indcrop.2012.11.030
DO - 10.1016/j.indcrop.2012.11.030
M3 - Artículo
SN - 0926-6690
VL - 44
SP - 336
EP - 342
JO - Industrial Crops and Products
JF - Industrial Crops and Products
ER -