TY - JOUR
T1 - Medicinal bismuth
T2 - Bismuth-organic frameworks as pharmaceutically privileged compounds
AU - Shetu, Shaila A.
AU - Sanchez-Palestino, Luis M.
AU - Rivera, Gildardo
AU - Bandyopadhyay, Debasish
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/12/17
Y1 - 2022/12/17
N2 - Historically organometallic compounds have been used to cure certain diseases with limited applications. Although bismuth belongs to the category of heavy metals, many of its derivatives have found applications in modern drug discovery research, mainly because of its low toxicity and higher bioavailability. Being an eco-friendly mild Lewis acid, compounds having bismuth as a central atom are capable of binding several proteins in humans and other species. Bismuth complexes demonstrated antibacterial potential in syphilis, diarrhea, gastritis, and colitis. Apart from antibacterial activities, bismuth compounds exhibited anticancer, antileishmanial, and some extent of antifungal and other medicinal properties. This article discusses major synthetic methods and pharmacological potentials of bismuth complexes exhibiting in vitro activity to significant clinical performance in a systematic and timely manner.
AB - Historically organometallic compounds have been used to cure certain diseases with limited applications. Although bismuth belongs to the category of heavy metals, many of its derivatives have found applications in modern drug discovery research, mainly because of its low toxicity and higher bioavailability. Being an eco-friendly mild Lewis acid, compounds having bismuth as a central atom are capable of binding several proteins in humans and other species. Bismuth complexes demonstrated antibacterial potential in syphilis, diarrhea, gastritis, and colitis. Apart from antibacterial activities, bismuth compounds exhibited anticancer, antileishmanial, and some extent of antifungal and other medicinal properties. This article discusses major synthetic methods and pharmacological potentials of bismuth complexes exhibiting in vitro activity to significant clinical performance in a systematic and timely manner.
KW - Anticancer
KW - Antimicrobial
KW - Bioactive compounds
KW - Bismuth complexes
KW - Bismuth heterocycles
KW - Green chemistry
UR - http://www.scopus.com/inward/record.url?scp=85142517433&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2022.133117
DO - 10.1016/j.tet.2022.133117
M3 - Artículo de revisión
AN - SCOPUS:85142517433
SN - 0040-4020
VL - 129
JO - Tetrahedron
JF - Tetrahedron
M1 - 133117
ER -