TY - JOUR
T1 - Mass spectrometry applied to the identification of Mycobacterium tuberculosis and biomarker discovery
AU - López-Hernández, Y.
AU - Patiño-Rodríguez, O.
AU - García-Orta, S. T.
AU - Pinos-Rodríguez, J. M.
N1 - Publisher Copyright:
© 2016 The Society for Applied Microbiology
PY - 2016/12/1
Y1 - 2016/12/1
N2 - An adequate and effective tuberculosis (TB) diagnosis system has been identified by the World Health Organization as a priority in the fight against this disease. Over the years, several methods have been developed to identify the bacillus, but bacterial culture remains one of the most affordable methods for most countries. For rapid and accurate identification, however, it is more feasible to implement molecular techniques, taking advantage of the availability of public databases containing protein sequences. Mass spectrometry (MS) has become an interesting technique for the identification of TB. Here, we review some of the most widely employed methods for identifying Mycobacterium tuberculosis and present an update on MS applied for the identification of mycobacterial species.
AB - An adequate and effective tuberculosis (TB) diagnosis system has been identified by the World Health Organization as a priority in the fight against this disease. Over the years, several methods have been developed to identify the bacillus, but bacterial culture remains one of the most affordable methods for most countries. For rapid and accurate identification, however, it is more feasible to implement molecular techniques, taking advantage of the availability of public databases containing protein sequences. Mass spectrometry (MS) has become an interesting technique for the identification of TB. Here, we review some of the most widely employed methods for identifying Mycobacterium tuberculosis and present an update on MS applied for the identification of mycobacterial species.
KW - Mycobacterium tuberculosis
KW - biomarker
KW - diagnosis
KW - identification
KW - mass spectrometry
UR - http://www.scopus.com/inward/record.url?scp=84995559844&partnerID=8YFLogxK
U2 - 10.1111/jam.13323
DO - 10.1111/jam.13323
M3 - Artículo de revisión
SN - 1364-5072
VL - 121
SP - 1485
EP - 1497
JO - Journal of Applied Microbiology
JF - Journal of Applied Microbiology
IS - 6
ER -