TY - JOUR
T1 - Magnetic nanoparticles
T2 - New players in antimicrobial peptide therapeutics
AU - López-Abarrategui, C.
AU - Figueroa-Espí, V.
AU - Reyes-Acosta, O.
AU - Reguera, E.
AU - Otero-Gonzalez, A. J.
PY - 2013
Y1 - 2013
N2 - Antimicrobial peptides are distributed in all forms of life presenting activity against bacteria, fungi, viruses, parasites and cancer. In spite of the tremendous potential of these molecules, very few of them have been successfully developed into therapeutics. The major problems associated with this new class of antimicrobials are molecule stability, toxicity in host cells and production cost. A novel strategy to overcome these obstacles is conjugation to nanomaterials. Magnetic nanoparticles have been widely studied in biomedicine due to their physicochemical properties. The conjugation of antimicrobial peptides to magnetic nanoparticles could combine the best properties of both, generating an improved antimicrobial nanoparticle. Here we provide an overview and discuss the potential application of magnetic nanoparticles conjugated to antimicrobial peptides in overcoming diseases.
AB - Antimicrobial peptides are distributed in all forms of life presenting activity against bacteria, fungi, viruses, parasites and cancer. In spite of the tremendous potential of these molecules, very few of them have been successfully developed into therapeutics. The major problems associated with this new class of antimicrobials are molecule stability, toxicity in host cells and production cost. A novel strategy to overcome these obstacles is conjugation to nanomaterials. Magnetic nanoparticles have been widely studied in biomedicine due to their physicochemical properties. The conjugation of antimicrobial peptides to magnetic nanoparticles could combine the best properties of both, generating an improved antimicrobial nanoparticle. Here we provide an overview and discuss the potential application of magnetic nanoparticles conjugated to antimicrobial peptides in overcoming diseases.
KW - Antimicrobial peptides
KW - Host defense peptides
KW - Immunomodulation
KW - Magnetic nanoparticles
KW - Therapeutics
UR - http://www.scopus.com/inward/record.url?scp=84888272710&partnerID=8YFLogxK
U2 - 10.2174/1389203711209070682
DO - 10.2174/1389203711209070682
M3 - Artículo
SN - 1389-2037
VL - 14
SP - 595
EP - 606
JO - Current Protein and Peptide Science
JF - Current Protein and Peptide Science
IS - 7
ER -