TY - JOUR
T1 - Low number of invariant NKT cells is associated with poor survival in acute myeloid leukemia
AU - Najera Chuc, Alicia E.
AU - Cervantes, Laura A.Montiel
AU - Retiguin, Flor Pérez
AU - Ojeda, Jorge Vela
AU - Maldonado, Elba Reyes
N1 - Funding Information:
Acknowledgments This work was supported in part by a grant from Fundación Gonzalo Río Arronte I.A.P. and by a grant from SIP-IPN 20110713. A. Nájera Chuc is a fellow of CONACYT (No. 205687); ERM is EDI and COFAA fellow. ERM, LAMC, and JVO are SNI fellows. The experiments performed in the present paper complied with the current laws of México and were approved by the Ethical Committee in ‘‘La Raza’’ Medical Center.
PY - 2012/8
Y1 - 2012/8
N2 - Background: T lymphocytes play an important role in the immunosurveillance of patients with hematologic malignancies. No study has so far examined the association between the number of lymphocyte subsets at diagnosis and overall survival (OS). We examined this relationship in adult patients with de novo acute myeloid leukemia (AML). Methods: A longitudinal prospective study was conducted on 28 AML patients. Peripheral blood (PB) and bone marrow (BM) were obtained before chemotherapy to quantify the number of CD4+ and CD8+ T cells, natural killer (NK), invariant NKT (iNKT), and type-1 and type-2 dendritic cells. The Kaplan-Meier and Cox proportional hazard model were used to determine significant association between the number of each cell subtype and survival. Results: BM counts of CD4+ lymphocytes >506.11/μL and CD8+ T lymphocytes >556.02/μL and a PB count of iNKT cells <0.2/μL were associated with poor OS by univariate analysis (P = 0.015, P = 0.009, P = 0.033 respectively). Multivariate analysis showed that an iNKT count <0.2 cells/μL is an independent prognostic factor for OS. Conclusion: An iNKT cell number of <0.2/μL confers a poor prognosis in de novo AML patients.
AB - Background: T lymphocytes play an important role in the immunosurveillance of patients with hematologic malignancies. No study has so far examined the association between the number of lymphocyte subsets at diagnosis and overall survival (OS). We examined this relationship in adult patients with de novo acute myeloid leukemia (AML). Methods: A longitudinal prospective study was conducted on 28 AML patients. Peripheral blood (PB) and bone marrow (BM) were obtained before chemotherapy to quantify the number of CD4+ and CD8+ T cells, natural killer (NK), invariant NKT (iNKT), and type-1 and type-2 dendritic cells. The Kaplan-Meier and Cox proportional hazard model were used to determine significant association between the number of each cell subtype and survival. Results: BM counts of CD4+ lymphocytes >506.11/μL and CD8+ T lymphocytes >556.02/μL and a PB count of iNKT cells <0.2/μL were associated with poor OS by univariate analysis (P = 0.015, P = 0.009, P = 0.033 respectively). Multivariate analysis showed that an iNKT count <0.2 cells/μL is an independent prognostic factor for OS. Conclusion: An iNKT cell number of <0.2/μL confers a poor prognosis in de novo AML patients.
KW - Acute Myeloid Leukemia
KW - Invariant NKT cells
KW - Lymphocyte subsets
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84864340451&partnerID=8YFLogxK
U2 - 10.1007/s00432-012-1251-x
DO - 10.1007/s00432-012-1251-x
M3 - Artículo
C2 - 22692855
SN - 0171-5216
VL - 138
SP - 1427
EP - 1432
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
IS - 8
ER -