TY - JOUR
T1 - Loci associated with genetic disorders and meat quality in Charolais cattle in Mexico
AU - Rincón, Ana María Sifuentes
AU - Vera, Williams Arellano
AU - Bracamonte, Gaspar Manuel Parra
AU - Morales, Pascuala Ambriz
AU - Bustamante, Luis Arístides López
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Allelic and genotypic frequencies of eight markers previously associated to genetic disorders and meat quality and located in the calpain (CAPN1-4751 and CAPN1-316) , calpastatin (CAST-T1), thyroglobulin (TG5), myostatin (MSTN, Q204X), argininosuccinate synthase (ASS), monophosphate synthase (UMPS) and myophosphorylase (PYGM) genes, were determined from 493 registered Charolais animals sampled from two herds located at Sonora (n= 157) and three at Nuevo León (n= 336), Mexico. No carriers of mutated alleles of ASS and UMPS genes were found, but carriers of the MSTN Q204X allele were identified at frequencies of ≤ 1 % in Sonora populations and 8.6 to 14.4 % in Nuevo Leon. In addition, carriers of PYGM marker were identified at frequencies of 6.49 and 1% in a herd from Sonora and other from Nuevo León, respectively. Analysis of gene differentiation among herds and with four loci showed that there are highly significant differences within Northwest populations (P<0.0001) and between them and the Northeast (P<0.001), differentiation is mainly explained by the loci CAPN-316 and TG5. According to the obtained results, the periodic monitoring of the PYGM marker gene and of the allele Q204X the MSTN gene is propose; also it is important to implement strategies to confirm the usefulness of those markers associated with quality and productivity as a tool to complement breeding programs.
AB - Allelic and genotypic frequencies of eight markers previously associated to genetic disorders and meat quality and located in the calpain (CAPN1-4751 and CAPN1-316) , calpastatin (CAST-T1), thyroglobulin (TG5), myostatin (MSTN, Q204X), argininosuccinate synthase (ASS), monophosphate synthase (UMPS) and myophosphorylase (PYGM) genes, were determined from 493 registered Charolais animals sampled from two herds located at Sonora (n= 157) and three at Nuevo León (n= 336), Mexico. No carriers of mutated alleles of ASS and UMPS genes were found, but carriers of the MSTN Q204X allele were identified at frequencies of ≤ 1 % in Sonora populations and 8.6 to 14.4 % in Nuevo Leon. In addition, carriers of PYGM marker were identified at frequencies of 6.49 and 1% in a herd from Sonora and other from Nuevo León, respectively. Analysis of gene differentiation among herds and with four loci showed that there are highly significant differences within Northwest populations (P<0.0001) and between them and the Northeast (P<0.001), differentiation is mainly explained by the loci CAPN-316 and TG5. According to the obtained results, the periodic monitoring of the PYGM marker gene and of the allele Q204X the MSTN gene is propose; also it is important to implement strategies to confirm the usefulness of those markers associated with quality and productivity as a tool to complement breeding programs.
KW - DNA
KW - Genetic defects
KW - Marbling
KW - Tenderness
UR - http://www.scopus.com/inward/record.url?scp=84952781356&partnerID=8YFLogxK
U2 - 10.22319/rmcp.v6i4.4098
DO - 10.22319/rmcp.v6i4.4098
M3 - Artículo
SN - 2007-1124
VL - 6
SP - 361
EP - 375
JO - Revista Mexicana De Ciencias Pecuarias
JF - Revista Mexicana De Ciencias Pecuarias
IS - 4
ER -