TY - JOUR
T1 - Lack of association of the polymorphisms IL-17A (-197G/A) and IL-17F (+7488A/G) with multibacillary leprosy in Mexican patients
AU - Escamilla-Tilch, Mónica
AU - Estrada-García, Iris
AU - Granados, Julio
AU - Arenas-Guzmán, Roberto
AU - Ramos-Payan, Rosalio
AU - Pérez-Suárez, Thalía Gabriela
AU - Salazar, Ma Isabel
AU - Pérez-Lucas, Riky Luis
AU - Estrada-Parra, Sergio
AU - Torres-Carrillo, Nora Magdalena
N1 - Publisher Copyright:
Copyright © 2014 Monica Escamilla-Tilch et al.
PY - 2014
Y1 - 2014
N2 - Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results.We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population.
AB - Background. Leprosy is a chronic infectious disease caused by the intracellular acid-fast bacilli Mycobacterium leprae; it has been determined that genetic factors of the host play an important role in the disease susceptibility. Thus, in this case-control study, we evaluated the possible association between the IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs and susceptibility to leprosy disease in Mexican population. Methods. Seventy-five leprosy patients and sixty-nine control subjects were included. Both SNPs were genotyped with the polymerase chain reaction-restriction fragment length polymorphism technique. Results.We found nonsignificant differences in genotype and allele frequencies related to IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780) gene SNPs in MB as well as subclinical forms of leprosy disease versus healthy individuals. Conclusions. Since the sample size is not large enough, it is difficult to sustain an association of susceptibility to leprosy with genotypes or allele frequencies of IL-17A G-197A (rs227593) and IL-17F A7488G (His161Arg, rs763780), suggesting that IL-17 polymorphisms have no significant role in the genetic susceptibility to development of this disease in the Mexican Mestizo population.
UR - http://www.scopus.com/inward/record.url?scp=84934986215&partnerID=8YFLogxK
U2 - 10.1155/2014/920491
DO - 10.1155/2014/920491
M3 - Artículo
AN - SCOPUS:84934986215
SN - 2314-436X
VL - 2014
JO - International Journal of Genomics
JF - International Journal of Genomics
M1 - 920491
ER -