TY - JOUR
T1 - Influence of proinflammatory cytokine gene polymorphisms on the risk of COPD and the levels of plasma protein
AU - Ambrocio-Ortiz, Enrique
AU - Pérez-Rubio, Gloria
AU - Abarca-Rojano, Edgar
AU - Montaño, Martha
AU - Ramos, Carlos
AU - Hernández-Zenteno, Rafael D.J.
AU - Del Angel-Pablo, Alma D.
AU - Reséndiz-Hernández, Juan M.
AU - Ramírez-Venegas, Alejandra
AU - Falfán-Valencia, Ramcés
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/11
Y1 - 2018/11
N2 - Introduction: Chronic obstructive pulmonary disease (COPD) is a complex and multifactorial disease involving systemic inflammation. Although certain genetic components have been implicated in the development and progression of this disease, few studies have examined the participation of polymorphisms in proinflammatory genes and the extent to which polymorphisms are related to plasma levels of cytokines involved in the inflammatory process. Methods: Of the 1125 smokers participating in the study, 438 had COPD, and 687 did not. We determined the genotype of 5 SNPs distributed in the genes: IL6, CXL8, CSF2, CCL1 and IL1B. The plasma protein expression of these genes was also evaluated and categorized according to genotype and the severity of COPD (GOLD grade). Results: An analysis using the codominant model showed an association between rs1818879 in IL6 and susceptibility to COPD (GA OR = 1.1, AA OR = 1.77; p < 0.01), as well as an association between rs25882 in CSF2 and a greater severity of the disease (TC OR = 1.84, CC OR = 3.62; p < 0.01). No association was found between the presence of certain alleles in the SNPs and the plasma levels of the corresponding proteins. Conclusions: There are genetic polymorphisms related to susceptibility to COPD (rs1818879/A in IL6), as well as to the risk of greater severity of the disease (rs25882/T in CSF2). The presence of the alleles of interest did not significantly affect plasma levels of the codified proteins.
AB - Introduction: Chronic obstructive pulmonary disease (COPD) is a complex and multifactorial disease involving systemic inflammation. Although certain genetic components have been implicated in the development and progression of this disease, few studies have examined the participation of polymorphisms in proinflammatory genes and the extent to which polymorphisms are related to plasma levels of cytokines involved in the inflammatory process. Methods: Of the 1125 smokers participating in the study, 438 had COPD, and 687 did not. We determined the genotype of 5 SNPs distributed in the genes: IL6, CXL8, CSF2, CCL1 and IL1B. The plasma protein expression of these genes was also evaluated and categorized according to genotype and the severity of COPD (GOLD grade). Results: An analysis using the codominant model showed an association between rs1818879 in IL6 and susceptibility to COPD (GA OR = 1.1, AA OR = 1.77; p < 0.01), as well as an association between rs25882 in CSF2 and a greater severity of the disease (TC OR = 1.84, CC OR = 3.62; p < 0.01). No association was found between the presence of certain alleles in the SNPs and the plasma levels of the corresponding proteins. Conclusions: There are genetic polymorphisms related to susceptibility to COPD (rs1818879/A in IL6), as well as to the risk of greater severity of the disease (rs25882/T in CSF2). The presence of the alleles of interest did not significantly affect plasma levels of the codified proteins.
KW - COPD
KW - Genes
KW - Mexican mestizo
KW - Proinflammatory cytokines
KW - SNP
UR - http://www.scopus.com/inward/record.url?scp=85054243376&partnerID=8YFLogxK
U2 - 10.1016/j.cyto.2018.09.017
DO - 10.1016/j.cyto.2018.09.017
M3 - Artículo
C2 - 30296713
SN - 1043-4666
VL - 111
SP - 364
EP - 370
JO - Cytokine
JF - Cytokine
ER -