TY - JOUR
T1 - Increased cell number with reduced nitric oxide level and augmented superoxide dismutase activity in the anterior-pituitary region of young suicide completers
AU - Baltazar-Gaytan, Eduardo
AU - Aguilar-Alonso, Patricia
AU - Brambila, Eduardo
AU - Tendilla-Beltran, Hiram
AU - Vázquez-Roque, Rubén Antonio
AU - Morales-Medina, Julio Cesar
AU - Maceda-Mártinez, Nestor
AU - Castro-Flores, Clara
AU - Susano-Pompeyo, Macario
AU - Garcés-Ramírez, Linda
AU - de la Cruz, Fidel
AU - García-Dolores, Fernando
AU - Flores, Gonzalo
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/3
Y1 - 2019/3
N2 - Suicidal behavior is a complex human behavior and current data suggests that suicide is an increasing cause of death among young people. The neurobiology of suicide is unknown and data investigating the role of the pituitary in suicidal behavior is scarce. Imaging data suggests that this gland increases in size in patients with major depression and recent data implicates hyperactivity of the hypothalamus-pituitary-adrenal axis in suicidal behavior. In this study, we evaluate the size and number of cells as well as markers related to oxidative stress and lipid peroxidation of the anterior and posterior sections of the pituitary gland of male suicide completers. Stereological analysis is used to quantify the total cell number in anterior- and posterior-pituitary regions. We examined nitric oxide (NO) levels, Zinc (Zn) levels, superoxide dismutase (SOD) activity, 4-hydroxy-alkenals (4-HDA), malondialdehyde (MDA) and metallothioneins (MTs). Our results indicate that the anterior-pituitary region of suicide completers exhibits increased weight, likely due to an enhanced number of cells compared to the control group. In addition, we found a reduction of NO levels with higher SOD activity in the anterior-pituitary region of suicide victims. No changes in Zn, MDA, MTs, 4-HDA or MDA were observed in tissue of suicide completers compared to the control group. This study demonstrates that there is an increased number of cells, with an imbalance in oxidative stress without a process of lipid peroxidation in the anterior-pituitary region of young male suicide completers.
AB - Suicidal behavior is a complex human behavior and current data suggests that suicide is an increasing cause of death among young people. The neurobiology of suicide is unknown and data investigating the role of the pituitary in suicidal behavior is scarce. Imaging data suggests that this gland increases in size in patients with major depression and recent data implicates hyperactivity of the hypothalamus-pituitary-adrenal axis in suicidal behavior. In this study, we evaluate the size and number of cells as well as markers related to oxidative stress and lipid peroxidation of the anterior and posterior sections of the pituitary gland of male suicide completers. Stereological analysis is used to quantify the total cell number in anterior- and posterior-pituitary regions. We examined nitric oxide (NO) levels, Zinc (Zn) levels, superoxide dismutase (SOD) activity, 4-hydroxy-alkenals (4-HDA), malondialdehyde (MDA) and metallothioneins (MTs). Our results indicate that the anterior-pituitary region of suicide completers exhibits increased weight, likely due to an enhanced number of cells compared to the control group. In addition, we found a reduction of NO levels with higher SOD activity in the anterior-pituitary region of suicide victims. No changes in Zn, MDA, MTs, 4-HDA or MDA were observed in tissue of suicide completers compared to the control group. This study demonstrates that there is an increased number of cells, with an imbalance in oxidative stress without a process of lipid peroxidation in the anterior-pituitary region of young male suicide completers.
KW - 4-Hydroxy-alkenals
KW - Malondialdehyde
KW - Metallothionein
KW - Nitric oxide
KW - Pituitary gland
KW - Stereology
KW - Suicide
KW - Superoxide dismutase activity
UR - http://www.scopus.com/inward/record.url?scp=85056743242&partnerID=8YFLogxK
U2 - 10.1016/j.jchemneu.2018.11.002
DO - 10.1016/j.jchemneu.2018.11.002
M3 - Artículo
C2 - 30423351
SN - 0891-0618
VL - 96
SP - 7
EP - 15
JO - Journal of Chemical Neuroanatomy
JF - Journal of Chemical Neuroanatomy
ER -