In silico testing of flavonoids as potential inhibitors of protease and helicase domains of dengue and Zika viruses

Medicina y ciencias biológicas

• Zika Virus 85%
• Dengue Virus 76%
• Molecular Dynamics Simulation 71%
• Protease Inhibitors 66%
• Flavonoids 65%
• Computer Simulation 60%
• Dengue 58%
• Quercetin 30%
• Drug Design 29%
• 3,5-dicaffeoylquinic acid 25%
• Serogroup 23%
• Catalytic Domain 23%
• Binding Sites 19%
• Ligands 18%
• Vector Borne Diseases 18%
• Rutin 17%
• Microcephaly 15%
• Pain 14%
• Myalgia 14%
• Medicinal Plants 13%
• Skeleton 13%
• Exanthema 12%
• Nausea 11%
• Vomiting 11%
• Antiviral Agents 11%
• Headache 11%
• Peptide Hydrolases 10%
• Software 9%
• Vaccines 9%
• Virus Diseases 9%
• RNA 8%
• Incidence 6%
• In Vitro Techniques 5%
• Therapeutics 2%

Agricultura y biología

• Zika virus 100%
• Dengue virus 86%
• proteinase inhibitors 68%
• molecular dynamics 68%
• dengue 51%
• flavonoids 49%
• drug design 32%
• quercetin 31%
• testing 25%
• pain 22%
• trajectories 22%
• active sites 20%
• ligands 19%
• serotypes 18%
• binding sites 18%
• nausea 15%
• vector-borne diseases 14%
• headache 14%
• vomiting 13%
• rutin 11%
• skeleton 10%
• signs and symptoms (animals and humans) 9%
• vaccines 9%
• medicinal plants 9%
• death 8%
• proteinases 8%
• incidence 7%
• RNA 7%
• muscles 7%
• acids 5%
• infection 5%
• methodology 2%

Química

• Flavonoid 61%
• Molecular Dynamics 47%
• Quercetin 41%
• Molecule 22%
• Binding Site 18%
• Simulation 16%
• Drug 13%
• Ligand 11%
• Block Like Crystal 8%
• Time 4%
• Acid 4%