TY - JOUR
T1 - In silico study of polyunsaturated fatty acids as potential sars-cov-2 spike protein closed conformation stabilizers
T2 - Epidemiological and computational approaches
AU - Vivar-Sierra, Alonso
AU - Araiza-Macías, María José
AU - Hernández-Contreras, José Patricio
AU - Vergara-Castañeda, Arely
AU - Ramírez-Vélez, Gabriela
AU - Pinto-Almazán, Rodolfo
AU - Salazar, Juan Rodrigo
AU - Loza-Mejía, Marco A.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - SARS-CoV-2 infects host cells by interacting its spike protein with surface angiotensin-converting enzyme 2 (ACE2) receptors, expressed in lung and other cell types. Although several risk factors could explain why some countries have lower incidence and fatality rates than others, environmental factors such as diet should be considered. It has been described that countries with high polyunsaturated fatty acid (PUFA) intake have a lower number of COVID-19 victims and a higher rate of recovery from the disease. Moreover, it was found that linoleic acid, an omega-6 PUFA, could stabilize the spike protein in a closed conformation, blocking its interaction with ACE2. These facts prompted us to perform in silico simulations to determine if other PUFA could also stabilize the closed conformation of spike protein and potentially lead to a reduction in SARS-CoV-2 infection. We found that: (a) countries whose source of omega-3 is from marine origin have lower fatality rates; and (b) like linoleic acid, omega-3 PUFA could also bind to the closed conformation of spike protein and therefore, could help reduce COVID-19 complications by reducing viral entrance to cells, in addition to their known anti-inflammatory effects.
AB - SARS-CoV-2 infects host cells by interacting its spike protein with surface angiotensin-converting enzyme 2 (ACE2) receptors, expressed in lung and other cell types. Although several risk factors could explain why some countries have lower incidence and fatality rates than others, environmental factors such as diet should be considered. It has been described that countries with high polyunsaturated fatty acid (PUFA) intake have a lower number of COVID-19 victims and a higher rate of recovery from the disease. Moreover, it was found that linoleic acid, an omega-6 PUFA, could stabilize the spike protein in a closed conformation, blocking its interaction with ACE2. These facts prompted us to perform in silico simulations to determine if other PUFA could also stabilize the closed conformation of spike protein and potentially lead to a reduction in SARS-CoV-2 infection. We found that: (a) countries whose source of omega-3 is from marine origin have lower fatality rates; and (b) like linoleic acid, omega-3 PUFA could also bind to the closed conformation of spike protein and therefore, could help reduce COVID-19 complications by reducing viral entrance to cells, in addition to their known anti-inflammatory effects.
KW - COVID-19
KW - DHA
KW - Molecular docking
KW - PUFA
KW - SARS-CoV-2
KW - Spike protein
UR - http://www.scopus.com/inward/record.url?scp=85101440597&partnerID=8YFLogxK
U2 - 10.3390/molecules26030711
DO - 10.3390/molecules26030711
M3 - Artículo
C2 - 33573088
AN - SCOPUS:85101440597
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 3
M1 - 711
ER -