TY - JOUR
T1 - In silico analysis of protein neoplastic biomarkers for cervix and uterine cancer
AU - Rodríguez-Pérez, Mario A.
AU - Medina-Aunon, Alberto
AU - Encarnación-Guevara, Sergio M.
AU - Bernal-Silvia, Sofia
AU - Barrera-Saldaña, Hugo
AU - Albar-Ramírez, Juan Pablo
N1 - Funding Information:
Acknowledgements The present article is an investigation realised in a sabbatical financed by the National Council of Science and Technology, México (CONACYT-Reference no. 76346). Mario A. Ro-dríguez-Pérez holds a scholarship from Comisión de Operación y Fomento de Actividades Académicas/Instituto Politécnico Nacional (IPN). Mario A. Rodríguez-Pérez is grateful for the support offered by the Centro Nacional de Biotecnología of Consejo Superior de In-vestigaciones Científicas (CNB-CSIC) in Madrid, Spain where he initiated studies on the search of human biomarkers in bio-fluids associable to different pathological stages by proteomics analysis. Sofia Bernal holds a doctoral scholarship from CONACYT-México and her thesis on biomarkers for risk of progression of VPH infections to cancer is being financed by the PACyT of the Universidad Autónoma de Nuevo León and CONACyT (México).
PY - 2008/10
Y1 - 2008/10
N2 - Worldwide, cervical and uterine cancers are the most deadly cancers in women, with high prevalences, especially in developing countries. The Human Protein Atlas (HPA) portal was explored for proteins expressed in a tissue- or cervix and uterine cancer-specific manner. The group of proteins differentially expressed and with enhanced expression in the glandular and surface epithelial (squamous) cells retrieved from HPA were further explored using the Protein Information and Knowledge Extractor (PIKE) portal to compile biological information that is found in different databases, and repositories on the Internet. Thus, the lists of candidate proteins found in HPA, and PIKE portals may be used as a starting point for the discovery and validation of biomarkers for cervix and uterine cancer employing proteomics approaches as described in the present article.
AB - Worldwide, cervical and uterine cancers are the most deadly cancers in women, with high prevalences, especially in developing countries. The Human Protein Atlas (HPA) portal was explored for proteins expressed in a tissue- or cervix and uterine cancer-specific manner. The group of proteins differentially expressed and with enhanced expression in the glandular and surface epithelial (squamous) cells retrieved from HPA were further explored using the Protein Information and Knowledge Extractor (PIKE) portal to compile biological information that is found in different databases, and repositories on the Internet. Thus, the lists of candidate proteins found in HPA, and PIKE portals may be used as a starting point for the discovery and validation of biomarkers for cervix and uterine cancer employing proteomics approaches as described in the present article.
KW - Cancer
KW - Differential quantitative proteomics
KW - Plasma and serum proteome
UR - http://www.scopus.com/inward/record.url?scp=58149392635&partnerID=8YFLogxK
U2 - 10.1007/s12094-008-0261-2
DO - 10.1007/s12094-008-0261-2
M3 - Artículo
C2 - 18940741
AN - SCOPUS:58149392635
SN - 1699-048X
VL - 10
SP - 604
EP - 617
JO - Clinical and Translational Oncology
JF - Clinical and Translational Oncology
IS - 10
ER -
