TY - JOUR
T1 - IgY Antibodies as Biotherapeutics in Biomedicine
AU - León-Núñez, Diana
AU - Vizcaíno-López, María Fernanda
AU - Escorcia, Magdalena
AU - Correa, Dolores
AU - Pérez-Hernández, Elizabeth
AU - Gómez-Chávez, Fernando
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/12
Y1 - 2022/12
N2 - Since the discovery of antibodies by Emil Von Behring and Shibasaburo Kitasato during the 19th century, their potential for use as biotechnological reagents has been exploited in different fields, such as basic and applied research, diagnosis, and the treatment of multiple diseases. Antibodies are relatively easy to obtain from any species with an adaptive immune system, but birds are animals characterized by relatively easy care and maintenance. In addition, the antibodies they produce can be purified from the egg yolk, allowing a system for obtaining them without performing invasive practices, which favors the three “rs” of animal care in experimentation, i.e., replacing, reducing, and refining. In this work, we carry out a brief descriptive review of the most outstanding characteristics of so-called “IgY technology” and the use of IgY antibodies from birds for basic experimentation, diagnosis, and treatment of human beings and animals.
AB - Since the discovery of antibodies by Emil Von Behring and Shibasaburo Kitasato during the 19th century, their potential for use as biotechnological reagents has been exploited in different fields, such as basic and applied research, diagnosis, and the treatment of multiple diseases. Antibodies are relatively easy to obtain from any species with an adaptive immune system, but birds are animals characterized by relatively easy care and maintenance. In addition, the antibodies they produce can be purified from the egg yolk, allowing a system for obtaining them without performing invasive practices, which favors the three “rs” of animal care in experimentation, i.e., replacing, reducing, and refining. In this work, we carry out a brief descriptive review of the most outstanding characteristics of so-called “IgY technology” and the use of IgY antibodies from birds for basic experimentation, diagnosis, and treatment of human beings and animals.
KW - IgY
KW - biotherapeutics
KW - diagnosis
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85144666816&partnerID=8YFLogxK
U2 - 10.3390/antib11040062
DO - 10.3390/antib11040062
M3 - Artículo de revisión
C2 - 36278615
AN - SCOPUS:85144666816
SN - 2073-4468
VL - 11
JO - Antibodies
JF - Antibodies
IS - 4
M1 - 62
ER -