Hibiscus Acid from Hibiscus sabdariffa L. Inhibits Flagellar Motility and Cell Invasion in Salmonella enterica

Ixchell Y. Sedillo-Torres; Álvaro O. Hernández-Rangel; Yolanda Gómez-Y-gómez; Daniel Cortés-Avalos; Blanca Estela García-Pérez; Juan C. Villalobos-Rocha; César H. Hernández-Rodríguez; Luis Gerardo Zepeda-Vallejo; Paulina Estrada De Los Santos; María Elena Vargas-Díaz; Jose Antonio Ibarra

doi:10.3390/molecules27030655

Hibiscus Acid from Hibiscus sabdariffa L. Inhibits Flagellar Motility and Cell Invasion in Salmonella enterica

Ixchell Y. Sedillo-Torres, Álvaro O. Hernández-Rangel, Yolanda Gómez-Y-gómez, Daniel Cortés-Avalos, Blanca Estela García-Pérez, Juan C. Villalobos-Rocha, César H. Hernández-Rodríguez, Luis Gerardo Zepeda-Vallejo, Paulina Estrada De Los Santos, María Elena Vargas-Díaz, Jose Antonio Ibarra

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Resumen

Extracts of Hibiscus sabdariffa L. (commonly called Rosselle or “Jamaica flower” in Mexico) have been shown to have antibiotic and antivirulence properties in several bacteria. Here, an organic extract of H. sabdariffa L. is shown to inhibit motility in Salmonella enterica serovars Typhi and Typhimurium. The compound responsible for this effect was purified and found to be the hibiscus acid. When tested, this compound also inhibited motility and reduced the secretion of both flagellin and type III secretion effectors. Purified hibiscus acid was not toxic in tissue-cultured eukaryotic cells, and it was able to reduce the invasion of Salmonella Typhimurium in epithelial cells. Initial steps to understand its mode of action showed it might affect membrane proton balance.

Idioma original	Inglés
Número de artículo	655
Publicación	Molecules
Volumen	27
N.º	3
DOI	https://doi.org/10.3390/molecules27030655
Estado	Publicada - 1 feb. 2022

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Sedillo-Torres, I. Y., Hernández-Rangel, Á. O., Gómez-Y-gómez, Y., Cortés-Avalos, D., García-Pérez, B. E., Villalobos-Rocha, J. C., Hernández-Rodríguez, C. H., Zepeda-Vallejo, L. G., Los Santos, P. E. D., Vargas-Díaz, M. E., & Ibarra, J. A. (2022). Hibiscus Acid from Hibiscus sabdariffa L. Inhibits Flagellar Motility and Cell Invasion in Salmonella enterica. Molecules, 27(3), Artículo 655. https://doi.org/10.3390/molecules27030655

@article{a6c20c75b8164d3099c18dcab747836a,

title = "Hibiscus Acid from Hibiscus sabdariffa L. Inhibits Flagellar Motility and Cell Invasion in Salmonella enterica",

abstract = "Extracts of Hibiscus sabdariffa L. (commonly called Rosselle or “Jamaica flower” in Mexico) have been shown to have antibiotic and antivirulence properties in several bacteria. Here, an organic extract of H. sabdariffa L. is shown to inhibit motility in Salmonella enterica serovars Typhi and Typhimurium. The compound responsible for this effect was purified and found to be the hibiscus acid. When tested, this compound also inhibited motility and reduced the secretion of both flagellin and type III secretion effectors. Purified hibiscus acid was not toxic in tissue-cultured eukaryotic cells, and it was able to reduce the invasion of Salmonella Typhimurium in epithelial cells. Initial steps to understand its mode of action showed it might affect membrane proton balance.",

keywords = "Antivirulence, Flagella, Hibiscus acid, Motility, Salmonella, Traditional medicine",

author = "Sedillo-Torres, {Ixchell Y.} and Hern{\'a}ndez-Rangel, {{\'A}lvaro O.} and Yolanda G{\'o}mez-Y-g{\'o}mez and Daniel Cort{\'e}s-Avalos and Garc{\'i}a-P{\'e}rez, {Blanca Estela} and Villalobos-Rocha, {Juan C.} and Hern{\'a}ndez-Rodr{\'i}guez, {C{\'e}sar H.} and Zepeda-Vallejo, {Luis Gerardo} and {Los Santos}, {Paulina Estrada De} and Vargas-D{\'i}az, {Mar{\'i}a Elena} and Ibarra, {Jose Antonio}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

day = "1",

doi = "10.3390/molecules27030655",

language = "Ingl{\'e}s",

volume = "27",

journal = "Molecules",

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Sedillo-Torres, IY, Hernández-Rangel, ÁO, Gómez-Y-gómez, Y, Cortés-Avalos, D, García-Pérez, BE , Villalobos-Rocha, JC , Hernández-Rodríguez, CH , Zepeda-Vallejo, LG , Los Santos, PED, Vargas-Díaz, ME & Ibarra, JA 2022, 'Hibiscus Acid from Hibiscus sabdariffa L. Inhibits Flagellar Motility and Cell Invasion in Salmonella enterica', Molecules, vol. 27, n.º 3, 655. https://doi.org/10.3390/molecules27030655

TY - JOUR

T1 - Hibiscus Acid from Hibiscus sabdariffa L. Inhibits Flagellar Motility and Cell Invasion in Salmonella enterica

AU - Sedillo-Torres, Ixchell Y.

AU - Hernández-Rangel, Álvaro O.

AU - Gómez-Y-gómez, Yolanda

AU - Cortés-Avalos, Daniel

AU - García-Pérez, Blanca Estela

AU - Villalobos-Rocha, Juan C.

AU - Hernández-Rodríguez, César H.

AU - Zepeda-Vallejo, Luis Gerardo

AU - Los Santos, Paulina Estrada De

AU - Vargas-Díaz, María Elena

AU - Ibarra, Jose Antonio

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Extracts of Hibiscus sabdariffa L. (commonly called Rosselle or “Jamaica flower” in Mexico) have been shown to have antibiotic and antivirulence properties in several bacteria. Here, an organic extract of H. sabdariffa L. is shown to inhibit motility in Salmonella enterica serovars Typhi and Typhimurium. The compound responsible for this effect was purified and found to be the hibiscus acid. When tested, this compound also inhibited motility and reduced the secretion of both flagellin and type III secretion effectors. Purified hibiscus acid was not toxic in tissue-cultured eukaryotic cells, and it was able to reduce the invasion of Salmonella Typhimurium in epithelial cells. Initial steps to understand its mode of action showed it might affect membrane proton balance.

AB - Extracts of Hibiscus sabdariffa L. (commonly called Rosselle or “Jamaica flower” in Mexico) have been shown to have antibiotic and antivirulence properties in several bacteria. Here, an organic extract of H. sabdariffa L. is shown to inhibit motility in Salmonella enterica serovars Typhi and Typhimurium. The compound responsible for this effect was purified and found to be the hibiscus acid. When tested, this compound also inhibited motility and reduced the secretion of both flagellin and type III secretion effectors. Purified hibiscus acid was not toxic in tissue-cultured eukaryotic cells, and it was able to reduce the invasion of Salmonella Typhimurium in epithelial cells. Initial steps to understand its mode of action showed it might affect membrane proton balance.

KW - Antivirulence

KW - Flagella

KW - Hibiscus acid

KW - Motility

KW - Salmonella

KW - Traditional medicine

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U2 - 10.3390/molecules27030655

DO - 10.3390/molecules27030655

M3 - Artículo

C2 - 35163919

AN - SCOPUS:85123112350

SN - 1420-3049

VL - 27

JO - Molecules

JF - Molecules

IS - 3

M1 - 655

ER -

Hibiscus Acid from Hibiscus sabdariffa L. Inhibits Flagellar Motility and Cell Invasion in Salmonella enterica

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