TY - JOUR
T1 - Hepatic carcinoma with spleen metastasis in a California sea lion from the Gulf of California
AU - Acevedo-Whitehouse, Karina A.
AU - Constantino-Casas, Fernando
AU - Aurioles-Gamboa, David
AU - Rodríguez-Martínez, Hector A.
AU - Godínez-Reyes, Carlos R.
PY - 1999/7
Y1 - 1999/7
N2 - A primary hepatic carcinoma with a neuroendocrine pattern was detected in an adult female California sea lion (Zalophus californianus) found dead on Granito Island in the Gulf of California (Mexico) in January 1996. At necropsy, several light yellow nodules of different sizes were observed on the entire surface of the liver and spleen. Microscopic examination of these nodules using routine haematoxylin-eosin stain, revealed cubic, polyhedral and pleomorphic cells with three to four bizarre mitotic figures per field (40x). An immunohistochemistry test revealed a positive reaction of indirect immunoperoxide to cytokeratin (CK2). This is the first known case of a primary hepatic carcinoma in free-ranging California sea lions from Mexican waters.
AB - A primary hepatic carcinoma with a neuroendocrine pattern was detected in an adult female California sea lion (Zalophus californianus) found dead on Granito Island in the Gulf of California (Mexico) in January 1996. At necropsy, several light yellow nodules of different sizes were observed on the entire surface of the liver and spleen. Microscopic examination of these nodules using routine haematoxylin-eosin stain, revealed cubic, polyhedral and pleomorphic cells with three to four bizarre mitotic figures per field (40x). An immunohistochemistry test revealed a positive reaction of indirect immunoperoxide to cytokeratin (CK2). This is the first known case of a primary hepatic carcinoma in free-ranging California sea lions from Mexican waters.
KW - California sea lion
KW - Case report
KW - Hepatic carcinoma
KW - Immunohistochemistry
KW - Neoplasm
KW - Pinnipeds
KW - Zalophus californianus
UR - http://www.scopus.com/inward/record.url?scp=0033163283&partnerID=8YFLogxK
U2 - 10.7589/0090-3558-35.3.565
DO - 10.7589/0090-3558-35.3.565
M3 - Artículo
SN - 0090-3558
VL - 35
SP - 565
EP - 568
JO - Journal of Wildlife Diseases
JF - Journal of Wildlife Diseases
IS - 3
ER -