TY - JOUR
T1 - Haemostatic role of intermediate filaments in adhered platelets
T2 - Importance of the membranous system stability
AU - Cerecedo, Doris
AU - Martínez-Vieyra, Ivette
AU - Mondragõn, Ricardo
AU - Mondragõn, Mõnica
AU - González, Sirenia
AU - Galván, Iván J.
PY - 2013/9
Y1 - 2013/9
N2 - The role of platelets in coagulation and the haemostatic process was initially suggested two centuries ago, and under appropriate physiological stimuli, these undergo abrupt morphological changes, attaching and spreading on damaged endothelium, preventing bleeding. During the adhesion process, platelet cytoskeleton reorganizes generating compartments in which actin filaments, microtubules, and associated proteins are arranged in characteristic patterns mediating crucial events, such as centralization of their organelles, secretion of granule contents, aggregation with one another to form a haemostatic plug, and retraction of these aggregates. However, the role of Intermediate filaments during the platelet adhesion process has not been explored.
AB - The role of platelets in coagulation and the haemostatic process was initially suggested two centuries ago, and under appropriate physiological stimuli, these undergo abrupt morphological changes, attaching and spreading on damaged endothelium, preventing bleeding. During the adhesion process, platelet cytoskeleton reorganizes generating compartments in which actin filaments, microtubules, and associated proteins are arranged in characteristic patterns mediating crucial events, such as centralization of their organelles, secretion of granule contents, aggregation with one another to form a haemostatic plug, and retraction of these aggregates. However, the role of Intermediate filaments during the platelet adhesion process has not been explored.
KW - Adhered Platelets
KW - Dystrophin-Associated Proteins (DAPs)
KW - Intermediate Filaments (IF)
KW - Plectin, Granulomere
UR - http://www.scopus.com/inward/record.url?scp=84881385868&partnerID=8YFLogxK
U2 - 10.1002/jcb.24546
DO - 10.1002/jcb.24546
M3 - Artículo
C2 - 23553987
SN - 0730-2312
VL - 114
SP - 2050
EP - 2060
JO - Journal of Cellular Biochemistry
JF - Journal of Cellular Biochemistry
IS - 9
ER -