TY - JOUR
T1 - Global Properties for A Virus Dynamics Model with Lytic and Non-Lytic Immune Responses, and Nonlinear Immune Attack Rates
AU - Vargas-De-León, Cruz
N1 - Publisher Copyright:
© 2014 World Scientific Publishing Company.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - We consider a mathematical model that describes a viral infection with lytic and non-lytic immune responses. One of the main features of the model is that it includes a rate of linear activation of cytotoxic T lymphocytes (CTLs) immune response, a constant production rate of CTLs export from thymus, and a nonlinear attack rate for each immune effector mechanism. Stability of the infection-free equilibrium, and existence, uniqueness and stability of an immune-controlled equilibrium, are investigated. The stability results are given in terms of the basic reproductive number. We use the method of Lyapunov functions to study the global stability of the infection-free equilibrium and the immune-controlled equilibrium. We give a sufficient condition on the non-lytic-immune attack rate for the global asymptotic stability of the immune-controlled equilibrium. By theoretical analysis and numerical simulations, we show that the lytic and non-lytic activities are required to combat a viral infection.
AB - We consider a mathematical model that describes a viral infection with lytic and non-lytic immune responses. One of the main features of the model is that it includes a rate of linear activation of cytotoxic T lymphocytes (CTLs) immune response, a constant production rate of CTLs export from thymus, and a nonlinear attack rate for each immune effector mechanism. Stability of the infection-free equilibrium, and existence, uniqueness and stability of an immune-controlled equilibrium, are investigated. The stability results are given in terms of the basic reproductive number. We use the method of Lyapunov functions to study the global stability of the infection-free equilibrium and the immune-controlled equilibrium. We give a sufficient condition on the non-lytic-immune attack rate for the global asymptotic stability of the immune-controlled equilibrium. By theoretical analysis and numerical simulations, we show that the lytic and non-lytic activities are required to combat a viral infection.
KW - Global Stability
KW - Immune Attack Rates
KW - Lyapunov Function
KW - Virus Dynamics
UR - http://www.scopus.com/inward/record.url?scp=84940233421&partnerID=8YFLogxK
U2 - 10.1142/S021833901450017X
DO - 10.1142/S021833901450017X
M3 - Artículo
SN - 0218-3390
VL - 22
SP - 449
EP - 462
JO - Journal of Biological Systems
JF - Journal of Biological Systems
IS - 3
ER -