TY - JOUR
T1 - Give boron a chance
T2 - Boron containing compounds reach ionotropic and metabotropic transmembrane receptors
AU - Soriano-Ursúa, M. A.
AU - Mancilla-Percino, T.
AU - Correa-Basurto, J.
AU - Querejeta, E.
AU - Trujillo-Ferrara, J. G.
PY - 2011/10
Y1 - 2011/10
N2 - The ligand-gated ion channels and seven transmembrane domain receptors are the greatest families of transmembrane receptors (TMR) expressed in mammalians and the major target of current available drugs. Recently, boron containing compounds (BCC) have shown capability of acting as ligands on these targets. This mini-review is focused on the description of BCC that target TMR which were evaluated under experimental models. The results in experimental models are related with the theoretical interaction studies of these ligands on the target proteins as 3D-models in order to explore the biological effects of BCC in molecular detail.
AB - The ligand-gated ion channels and seven transmembrane domain receptors are the greatest families of transmembrane receptors (TMR) expressed in mammalians and the major target of current available drugs. Recently, boron containing compounds (BCC) have shown capability of acting as ligands on these targets. This mini-review is focused on the description of BCC that target TMR which were evaluated under experimental models. The results in experimental models are related with the theoretical interaction studies of these ligands on the target proteins as 3D-models in order to explore the biological effects of BCC in molecular detail.
KW - 7TM receptor
KW - Boron containing compound
KW - Channel receptor
KW - Drug development
KW - Molecular recognition
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=82955226061&partnerID=8YFLogxK
U2 - 10.2174/138955711797247743
DO - 10.2174/138955711797247743
M3 - Artículo de revisión
SN - 1389-5575
VL - 11
SP - 1031
EP - 1038
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 12
ER -