TY - JOUR
T1 - Genetic polymorphisms of interleukin-1 alpha and the vitamin D receptor in mexican mestizo patients with intervertebral disc degeneration
AU - Cervin Serrano, Salvador
AU - González Villareal, Dalia
AU - Aguilar-Medina, Maribel
AU - Romero-Navarro, Jose Guillermo
AU - Romero Quintana, Jose Geovanni
AU - Arámbula Meraz, Eliakym
AU - Osuna Ramírez, Ignacio
AU - Picos-Cárdenas, Veronica
AU - Granados, Julio
AU - Estrada-García, Iris
AU - Sánchez-Schmitz, Guzman
AU - Ramos-Payán, Rosalío
N1 - Publisher Copyright:
© 2014 Salvador Cervin Serrano et al.
PY - 2014
Y1 - 2014
N2 - Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between rs1800587 (c.-949C>T) of interleukin-1 alpha (IL1A) and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of vitamin D receptor (VDR) gene polymorphisms and the development of IDD in northwestern Mexican Mestizo population. Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDD n = 100 and subjects with normal lumbar-spine MRI-scans n = 100. Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0% P = 0.455 for T of rs1800587 (IL1A); 53.0% versus 58.0% P = 0.183 for V of rs2228570 (VDR); and 18.0% versus 21.0% P = 0.262 for C of rs731236 (VDR). Our results showed no association between the studied polymorphisms and IDD in this population. This is the first report on the contribution of gene polymorphisms on IDD in a Mexican population.
AB - Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between rs1800587 (c.-949C>T) of interleukin-1 alpha (IL1A) and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of vitamin D receptor (VDR) gene polymorphisms and the development of IDD in northwestern Mexican Mestizo population. Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDD n = 100 and subjects with normal lumbar-spine MRI-scans n = 100. Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0% P = 0.455 for T of rs1800587 (IL1A); 53.0% versus 58.0% P = 0.183 for V of rs2228570 (VDR); and 18.0% versus 21.0% P = 0.262 for C of rs731236 (VDR). Our results showed no association between the studied polymorphisms and IDD in this population. This is the first report on the contribution of gene polymorphisms on IDD in a Mexican population.
UR - http://www.scopus.com/inward/record.url?scp=84919346740&partnerID=8YFLogxK
U2 - 10.1155/2014/302568
DO - 10.1155/2014/302568
M3 - Artículo
SN - 2314-436X
VL - 2014
JO - International Journal of Genomics
JF - International Journal of Genomics
M1 - 302568
ER -