TY - JOUR
T1 - Functionality of Prosolv Easytab as direct compression excipient
AU - Rodríguez Valadez, Jesús A.
AU - Villafuerte Robles, Leopoldo
PY - 2013
Y1 - 2013
N2 - Specific values of the excipient physical, chemical and technological properties identify its functionality. These concrete values allow the establishment of statistical parameters to use it as excipient. The purpose of the work is the evaluation of Prosolv Easytab as excipient for direct compression. The evaluated parameters included tablet crushing strength y lubricity profiles and particle size of the excipient. The maximal tablet crushing strength Dmax = 265 ± 12 N defines the surrogate functionality of Easytab as a binder while its explicit functionality to improve metronidazole's compactibility (Dmax) was 2.25 N per unit percentage Easytab in the formula. The ejection pressure for Easytab tablets was defined as 3.88 ± 0.27 MPa while its particle size was d50% = 158 ± 21 μm, with a dispersion degree of 0.308 ± 0.025. The calculated parameters allow the reduction of the excipient functionality to numerical values that characterizes the material's functionality and its lot-to-lot variability.
AB - Specific values of the excipient physical, chemical and technological properties identify its functionality. These concrete values allow the establishment of statistical parameters to use it as excipient. The purpose of the work is the evaluation of Prosolv Easytab as excipient for direct compression. The evaluated parameters included tablet crushing strength y lubricity profiles and particle size of the excipient. The maximal tablet crushing strength Dmax = 265 ± 12 N defines the surrogate functionality of Easytab as a binder while its explicit functionality to improve metronidazole's compactibility (Dmax) was 2.25 N per unit percentage Easytab in the formula. The ejection pressure for Easytab tablets was defined as 3.88 ± 0.27 MPa while its particle size was d50% = 158 ± 21 μm, with a dispersion degree of 0.308 ± 0.025. The calculated parameters allow the reduction of the excipient functionality to numerical values that characterizes the material's functionality and its lot-to-lot variability.
KW - Excipient functionality
KW - Lubricity
KW - Mechanical strength
KW - Particle size
UR - http://www.scopus.com/inward/record.url?scp=84890514039&partnerID=8YFLogxK
M3 - Artículo
SN - 0326-2383
VL - 32
SP - 1476
EP - 1484
JO - Latin American Journal of Pharmacy
JF - Latin American Journal of Pharmacy
IS - 10
ER -