TY - JOUR
T1 - Extracellular proteases of Staphylococcus epidermidis
T2 - roles as virulence factors and their participation in biofilm
AU - Martínez-García, Sergio
AU - Rodríguez-Martínez, Sandra
AU - Cancino-Diaz, Mario E.
AU - Cancino-Diaz, Juan C.
N1 - Publisher Copyright:
© 2018 APMIS. Published by John Wiley & Sons Ltd
PY - 2018/3
Y1 - 2018/3
N2 - Staphylococci produce a large number of extracellular proteases, some of which are considered as potential virulence factors. Staphylococcus epidermidis is a causative agent of nosocomial infections in medical devices by the formation of biofilms. It has been proposed that proteases contribute to the different stages of biofilm formation. S. epidermidis secretes a small number of extracellular proteases, such as serine protease Esp, cysteine protease EcpA, and metalloprotease SepA that have a relatively low substrate specificity. Recent findings indicate a significant contribution of extracellular proteases in biofilm formation through the proteolytic inactivation of adhesion molecules. The objective of this work is to provide an overview of the current knowledge of S. epidermidis’ extracellular proteases during pathogenicity, especially in the different stages of biofilm formation.
AB - Staphylococci produce a large number of extracellular proteases, some of which are considered as potential virulence factors. Staphylococcus epidermidis is a causative agent of nosocomial infections in medical devices by the formation of biofilms. It has been proposed that proteases contribute to the different stages of biofilm formation. S. epidermidis secretes a small number of extracellular proteases, such as serine protease Esp, cysteine protease EcpA, and metalloprotease SepA that have a relatively low substrate specificity. Recent findings indicate a significant contribution of extracellular proteases in biofilm formation through the proteolytic inactivation of adhesion molecules. The objective of this work is to provide an overview of the current knowledge of S. epidermidis’ extracellular proteases during pathogenicity, especially in the different stages of biofilm formation.
KW - EcpA
KW - Esp
KW - Proteases
KW - SepA
KW - Staphylococcus epidermidis
KW - biofilm
UR - http://www.scopus.com/inward/record.url?scp=85041590543&partnerID=8YFLogxK
U2 - 10.1111/apm.12805
DO - 10.1111/apm.12805
M3 - Artículo de revisión
C2 - 29399876
SN - 0903-4641
VL - 126
SP - 177
EP - 185
JO - APMIS
JF - APMIS
IS - 3
ER -