TY - JOUR
T1 - Expression and regulation of chemokines in mycobacterial infection
AU - Méndez-Samperio, Patricia
N1 - Funding Information:
This work was supported by grant 20080419 from the Coordinación General de Posgrado e Investigación de el IPN (CGPI). PMS is a COFAA, EDI, and SNI fellow.
PY - 2008/11
Y1 - 2008/11
N2 - Chemokines are the key molecules that recruit immune cells by chemotaxis and act in leukocyte activation during mycobacterial diseases. Currently, tuberculosis is a leading infectious disease affecting millions of people worldwide. The purpose of this review is to describe a series of recent scientific evidence concerning to the protective role of some members of the CC- and the CXC chemokine subfamilies for the control of mycobacterial infection. The discussion will (1) highlight the effectiveness of some chemokines as potent immunoprophylactic tool for controlling the mycobacterial establishment within the host, (2) describe recent work on the relevance of cellular signaling pathways by which mycobacterial antigens mediate chemokine induction, and (3) summarize current progress in the understanding of the potential use of chemokines as potent adjuvants in antimycobacterial immune responses.
AB - Chemokines are the key molecules that recruit immune cells by chemotaxis and act in leukocyte activation during mycobacterial diseases. Currently, tuberculosis is a leading infectious disease affecting millions of people worldwide. The purpose of this review is to describe a series of recent scientific evidence concerning to the protective role of some members of the CC- and the CXC chemokine subfamilies for the control of mycobacterial infection. The discussion will (1) highlight the effectiveness of some chemokines as potent immunoprophylactic tool for controlling the mycobacterial establishment within the host, (2) describe recent work on the relevance of cellular signaling pathways by which mycobacterial antigens mediate chemokine induction, and (3) summarize current progress in the understanding of the potential use of chemokines as potent adjuvants in antimycobacterial immune responses.
KW - Cell signaling
KW - Chemokines
KW - Infection
KW - M. bovis BCG
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=55949120073&partnerID=8YFLogxK
U2 - 10.1016/j.jinf.2008.08.010
DO - 10.1016/j.jinf.2008.08.010
M3 - Artículo de revisión
C2 - 18838171
SN - 0163-4453
VL - 57
SP - 374
EP - 384
JO - Journal of Infection
JF - Journal of Infection
IS - 5
ER -