Expresión de las sintasas de óxido nítrico inducida por lipopolisacárido en cerebro de ratas

Dolores Javier Sánchez-González, Gerardo Martín González-López, Carlos Armando Sosa-Luna, Nayeli Isabel Trejo-Bahena, Claudia María Martínez-Martínez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Introduction. Nitric oxide (NO) is formed from the amino acid L-arginine by a family of enzymes, the NO synthases (NOSs), and plays a role in many physiological functions. NO is synthesized in neurons of the central nervous system, where it acts as a neuromediator with many physiological functions, including the formation of memory, coordination between neuronal activity and blood flow, and modulation of pain. In the peripheral nervous system, NO is now known to be the mediator released by a widespread network of nerves, previously recognized as nonadrenergic and noncholinergic. These nerves mediate some forms of neurogenic vasodilation and regulate certain gastrointestinal, respiratory and genitourinary functions. NOS is a heme-containing enzyme with a sequence similarity to cytochrome P-450 reductase. Several isoforms of NOS are now known to exist, two of which are constitutive; neuronal and endothelial and one of which is inducible by LPS (nNOS, eNOS and iNOS, respectively). Objective. To explore expression and immunolocalization of NOSs in brains isolated from male Wistar rats by LPS. Methodology. In our model, we used immunohistochemistry technique. Results. We found moderate expression of NOSs in basal nuclei, while in rhinencephalo and olfactory tracts it was abundant expression.

Título traducido de la contribuciónExpression of the synthases of nitric oxide induced for lipopolysaccharide in brain of rates
Idioma originalEspañol
Páginas (desde-hasta)1-8
Número de páginas8
PublicaciónNeurologia, Neurocirugia y Psiquiatria
Volumen41
N.º1
EstadoPublicada - ene 2008

Palabras clave

  • Nitrergic neurons
  • Nitric oxide

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