TY - JOUR
T1 - Evidence of some natural products with antigenotoxic effects. Part 2
T2 - Plants, vegetables, and natural resin
AU - López-Romero, David
AU - Izquierdo-Vega, Jeannett A.
AU - Morales-González, José Antonio
AU - Madrigal-Bujaidar, Eduardo
AU - Chamorro-Cevallos, Germán
AU - Sánchez-Gutiérrez, Manuel
AU - Betanzos-Cabrera, Gabriel
AU - Alvarez-Gonzalez, Isela
AU - Morales-González, Ángel
AU - Madrigal-Santillán, Eduardo
N1 - Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/12/10
Y1 - 2018/12/10
N2 - Cancer is one of the leading causes of death worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens, or teratogens. Genotoxins are also involved in the pathogenesis of several chronic degenerative diseases, including hepatic, neurodegenerative, and cardiovascular disorders; diabetes; arthritis; cancer; chronic inflammation; and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown the antigenotoxic potential of different fruits and plants (Part 1). In this review (Part 2), we present a research overview conducted on some plants and vegetables (spirulina, broccoli, chamomile, cocoa, ginger, laurel, marigold, roselle, and rosemary), which are frequently consumed by humans. In addition, an analysis of some phytochemicals extracted from those vegetables and the analysis of a resin (propolis),whose antigenotoxic power has been demonstrated in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay, was also performed.
AB - Cancer is one of the leading causes of death worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens, or teratogens. Genotoxins are also involved in the pathogenesis of several chronic degenerative diseases, including hepatic, neurodegenerative, and cardiovascular disorders; diabetes; arthritis; cancer; chronic inflammation; and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown the antigenotoxic potential of different fruits and plants (Part 1). In this review (Part 2), we present a research overview conducted on some plants and vegetables (spirulina, broccoli, chamomile, cocoa, ginger, laurel, marigold, roselle, and rosemary), which are frequently consumed by humans. In addition, an analysis of some phytochemicals extracted from those vegetables and the analysis of a resin (propolis),whose antigenotoxic power has been demonstrated in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay, was also performed.
KW - Antigenotoxic
KW - Cancer
KW - Comet assay
KW - Micronucleus
KW - Plants
KW - Propolis
KW - Vegetables
UR - http://www.scopus.com/inward/record.url?scp=85058762077&partnerID=8YFLogxK
U2 - 10.3390/nu10121954
DO - 10.3390/nu10121954
M3 - Artículo de revisión
C2 - 30544726
AN - SCOPUS:85058762077
SN - 2072-6643
VL - 10
JO - Nutrients
JF - Nutrients
IS - 12
M1 - 1954
ER -