TY - JOUR
T1 - Evidence for suppression of Onchocerca volvulus transmission in the Oaxaca focus in Mexico
AU - Rodríguez-Pérez, Mario A.
AU - Lizarazo-Ortega, Cristian
AU - Hassan, Hassan K.
AU - Domínguez-Vásquez, Alfredo
AU - Méndez-Galván, Jorge
AU - Lugo-Moreno, Patricia
AU - Sauerbrey, Mauricio
AU - Richards, Frank
AU - Unnasch, Thomas R.
PY - 2008/1
Y1 - 2008/1
N2 - Entomologic and serologic surveys were performed in four sentinel communities in the Oaxaca focus in southern Mexico to assess the level of transmission and exposure incidence to Onchocerca volvulus. All communities have been receiving ivermectin mass treatment twice per year since 1997. In one community, parasite DNA was detected by polymerase chain reaction-enzyme-linked immunosorbent assay in 2004 in one pool of 50 vector heads of 170 such pools (8,500 flies) examined, which indicated an estimated transmission potential of 6.7 third-stage larvae/person/year. No evidence for transmission was found in the three other communities in 13,650 flies examined. All persons in a cohort consisting of 117 children in the four communities remained serologically negative for antibodies recognizing a cocktail of recombinant antigens over a four-year period from 2001 to 2004, which indicated an exposure incidence of 0%. Taken together, these data suggest that transmission has been suppressed in the four communities.
AB - Entomologic and serologic surveys were performed in four sentinel communities in the Oaxaca focus in southern Mexico to assess the level of transmission and exposure incidence to Onchocerca volvulus. All communities have been receiving ivermectin mass treatment twice per year since 1997. In one community, parasite DNA was detected by polymerase chain reaction-enzyme-linked immunosorbent assay in 2004 in one pool of 50 vector heads of 170 such pools (8,500 flies) examined, which indicated an estimated transmission potential of 6.7 third-stage larvae/person/year. No evidence for transmission was found in the three other communities in 13,650 flies examined. All persons in a cohort consisting of 117 children in the four communities remained serologically negative for antibodies recognizing a cocktail of recombinant antigens over a four-year period from 2001 to 2004, which indicated an exposure incidence of 0%. Taken together, these data suggest that transmission has been suppressed in the four communities.
UR - http://www.scopus.com/inward/record.url?scp=39049093086&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2008.78.147
DO - 10.4269/ajtmh.2008.78.147
M3 - Artículo
SN - 0002-9637
VL - 78
SP - 147
EP - 152
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 1
ER -