TY - JOUR
T1 - Evaluation of antioxidant enzymes in response to predator odor stress in prefrontal cortex and amygdala
AU - Mejia-Carmona, G. E.
AU - Gosselink, K. L.
AU - de la Rosa, L. A.
AU - Pérez-Ishiwara, G.
AU - Martínez-Martínez, A.
N1 - Funding Information:
This work was supported by Grant 5G12MD007592 from the National Institutes on Minority Health and Health Disparities (NIMHD), and Grant 1R24DA029989 from the National Insti tute on Drug Abuse (NIDA), components of the National Institutes of Health (NIH).
Funding Information:
CONACyT (Fondo 10013) grants 91191 and 89791; Universidad Autónoma de Ciudad Juárez and Escuela Nacional de Medicina y Homeopatia Insti tuto Politécnico Nacional. Mejia Carmona GE acknowledges a fellowship by CONACyT and support by UACJ.
PY - 2014/4
Y1 - 2014/4
N2 - Conditions of stress can originate from diverse stimuli including physical, chemical, antigenic and psychological. The latter is processed in part via the hypothalamic-pituitary-adrenal (HPA) axis, with input from and communication between the amygdala (AM) and prefrontal cortex (PFC). The HPA axis generates an increase in circulating glucocorticoids, augmenting metabolism and, consequently, oxygen consumption, increasing the production of free radicals and reactive oxygen species (ROS). Exposure to predator odor as a model of non-invasive acute stress was used to evaluate the hypothesis that psychogenic stress can modify enzymatic antioxidant responses. The activities of various enzymes, catalase (CAT), cytosolic and mitochondrial superoxide dismutase (Cu, Zn-SOD and Mn-SOD, respectively) and glutathione S-transferase (GST), were determined in AM and PFC. Acute psychogenic stress inhibited CAT activity in the AM and PFC, and increased Mn-SOD activity in the PFC. These results demonstrate that different responses can be elicited by the same stressor in two separate brain regions involved in processing emotional stimuli, and that changes in specific antioxidant enzymatic responses can be seen with exposure to acute psychogenic stress.
AB - Conditions of stress can originate from diverse stimuli including physical, chemical, antigenic and psychological. The latter is processed in part via the hypothalamic-pituitary-adrenal (HPA) axis, with input from and communication between the amygdala (AM) and prefrontal cortex (PFC). The HPA axis generates an increase in circulating glucocorticoids, augmenting metabolism and, consequently, oxygen consumption, increasing the production of free radicals and reactive oxygen species (ROS). Exposure to predator odor as a model of non-invasive acute stress was used to evaluate the hypothesis that psychogenic stress can modify enzymatic antioxidant responses. The activities of various enzymes, catalase (CAT), cytosolic and mitochondrial superoxide dismutase (Cu, Zn-SOD and Mn-SOD, respectively) and glutathione S-transferase (GST), were determined in AM and PFC. Acute psychogenic stress inhibited CAT activity in the AM and PFC, and increased Mn-SOD activity in the PFC. These results demonstrate that different responses can be elicited by the same stressor in two separate brain regions involved in processing emotional stimuli, and that changes in specific antioxidant enzymatic responses can be seen with exposure to acute psychogenic stress.
KW - amygdala
KW - catalase
KW - glutathione S-transferase
KW - oxidative stress
KW - prefrontal cortex
KW - psychogenic stress
KW - superoxide dismutase
UR - http://www.scopus.com/inward/record.url?scp=84901947525&partnerID=8YFLogxK
U2 - 10.1134/S181971241402007X
DO - 10.1134/S181971241402007X
M3 - Artículo
SN - 1819-7124
VL - 8
SP - 125
EP - 128
JO - Neurochemical Journal
JF - Neurochemical Journal
IS - 2
ER -