TY - JOUR
T1 - Endothelial nitric oxide synthase gene polymorphism in the Indian and Mestizo populations of Mexico
AU - Rosas-Vargas, Haydeé
AU - Flores-Segura, Adrián
AU - Guizada-Claure, Boris
AU - Vargas-Alarcón, Gilberto
AU - Granados, Julio
AU - Salamanca, Fabio
AU - Coral-Vázquez, Ramón
PY - 2003/2
Y1 - 2003/2
N2 - Endothelium-derived nitric oxide (NO) is an important factor in vasodilation synthesized by endothelial nitric oxide synthase (eNOS). A polymorphism (894 G to T) in exon 7 of the eNOS gene causes the conversion of Glu to Asp in position 298. The Glu298Asp polymorphism has been extensively associated with cardiovascular disease. We determined the Glu298Asp polymorphism frequency in healthy Mexican Mestizo, Huastec, Mayo, and Mayan populations by the endonuclease restriction method. The four populations analyzed were in Hardy-Weinberg equilibrium. Allele frequencies were similar among Mexican populations but different when compared with Caucasians. However, when compared with allele frequencies in Asian populations, Mestizo and Huastec allele frequencies were significantly different. Genotypically, only the Mestizos presented Asp298 homozygosity. The absence of double mutants in Indian populations resembles that in Asians. With these data, we conclude that the low frequency of the eNOS Glu298Asp polymorphism in Indian and Mestizo populations of Mexico is related to the Asian origin of Amerindian groups.
AB - Endothelium-derived nitric oxide (NO) is an important factor in vasodilation synthesized by endothelial nitric oxide synthase (eNOS). A polymorphism (894 G to T) in exon 7 of the eNOS gene causes the conversion of Glu to Asp in position 298. The Glu298Asp polymorphism has been extensively associated with cardiovascular disease. We determined the Glu298Asp polymorphism frequency in healthy Mexican Mestizo, Huastec, Mayo, and Mayan populations by the endonuclease restriction method. The four populations analyzed were in Hardy-Weinberg equilibrium. Allele frequencies were similar among Mexican populations but different when compared with Caucasians. However, when compared with allele frequencies in Asian populations, Mestizo and Huastec allele frequencies were significantly different. Genotypically, only the Mestizos presented Asp298 homozygosity. The absence of double mutants in Indian populations resembles that in Asians. With these data, we conclude that the low frequency of the eNOS Glu298Asp polymorphism in Indian and Mestizo populations of Mexico is related to the Asian origin of Amerindian groups.
KW - Cardiovascular disease
KW - Genetics
KW - Latin America
KW - NOS polymorphism
UR - http://www.scopus.com/inward/record.url?scp=0037309403&partnerID=8YFLogxK
U2 - 10.1353/hub.2003.0027
DO - 10.1353/hub.2003.0027
M3 - Artículo
SN - 0018-7143
VL - 75
SP - 91
EP - 96
JO - Human Biology
JF - Human Biology
IS - 1
ER -