Resumen
To better understand the significant variability displayed by influenza viruses, we need to be aware not only of its genetic characteristics, but also of the effect this genetic makeup has on proteins associated with viral replication and antigenicity. The origin of such diversity is due first and foremost to its segmented genome that allows segment reassortment (antigenic shift) and second to the error prone viral polymerase (antigenic drift) responsible of copying the genes enclosed in these segments. These two combined mechanisms confer a genetic plasticity that often leads to the emergence of new influenza viruses in nature.
Título traducido de la contribución | The origin of genetic variability of the influenza virus |
---|---|
Idioma original | Español |
Páginas (desde-hasta) | 199-206 |
Número de páginas | 8 |
Publicación | Gaceta Medica de Mexico |
Volumen | 146 |
N.º | 3 |
Estado | Publicada - may. 2010 |
Palabras clave
- Error-prone polymerase
- Genetic variability
- Influenza virus
- Segmented genome