TY - JOUR
T1 - Metabolic status and its association with bone activity in post-menopausal women
AU - Córdova Pérez, N.
AU - Basurto Acevedo, M. L.
AU - Saucedo García, R. P.
AU - Rodríguez Luna, A. K.
AU - Rosales Cruz, E.
AU - Arregoitia Sarabia, C. K.
AU - Hernández Valencia, M.
AU - Sosa García, B. C.
AU - Reyes Maldonado, E.
N1 - Publisher Copyright:
© 2017 Elsevier España, S.L.U.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Introduction and objective: Changes in lipid metabolism, insulin sensitivity, and visceral adipose tissue increase cardio-metabolic risk. Recent evidence suggests that osteocalcin (OCN) may play a role in metabolism. However, little is known about the OCN in post-menopausal women. The aim of this study was to investigate the relationship between the concentration of OCN with obesity and metabolic syndrome (MS) in pre-and post-menopausal women. Methods: A cross-sectional study was conducted that included 261 participants who were reviewed clinically and underwent laboratory studies, including the determination of serum OCN and insulin by chemiluminescence. Results: Of the participants, 128 were pre-menopausal, 133 post-menopausal, and 33% had MS. OCN concentration was higher in post-menopausal women than in pre-menopausal (7.7 ± 5.7 vs. 5.3 + 2.6 ng/mL, P<.001). OCN levels in post-menopausal women with MS were greater than those without MS (8.4 ± 5.1 vs 6.3 ± 2.8 ng/mL, P.003). Conclusion: Oestrogen deficiency and insulin resistance are associated with increased OCN during the stage of post-menopausal stage.
AB - Introduction and objective: Changes in lipid metabolism, insulin sensitivity, and visceral adipose tissue increase cardio-metabolic risk. Recent evidence suggests that osteocalcin (OCN) may play a role in metabolism. However, little is known about the OCN in post-menopausal women. The aim of this study was to investigate the relationship between the concentration of OCN with obesity and metabolic syndrome (MS) in pre-and post-menopausal women. Methods: A cross-sectional study was conducted that included 261 participants who were reviewed clinically and underwent laboratory studies, including the determination of serum OCN and insulin by chemiluminescence. Results: Of the participants, 128 were pre-menopausal, 133 post-menopausal, and 33% had MS. OCN concentration was higher in post-menopausal women than in pre-menopausal (7.7 ± 5.7 vs. 5.3 + 2.6 ng/mL, P<.001). OCN levels in post-menopausal women with MS were greater than those without MS (8.4 ± 5.1 vs 6.3 ± 2.8 ng/mL, P.003). Conclusion: Oestrogen deficiency and insulin resistance are associated with increased OCN during the stage of post-menopausal stage.
KW - Menopause
KW - Metabolic syndrome
KW - Osteocalcin
UR - http://www.scopus.com/inward/record.url?scp=85035000805&partnerID=8YFLogxK
U2 - 10.1016/j.gine.2017.10.001
DO - 10.1016/j.gine.2017.10.001
M3 - Artículo
SN - 0210-573X
VL - 46
SP - 51
EP - 56
JO - Clinica e Investigacion en Ginecologia y Obstetricia
JF - Clinica e Investigacion en Ginecologia y Obstetricia
IS - 2
ER -