TY - JOUR
T1 - Efficient preparation of α-ketoacetals
AU - Ayala-Mata, Francisco
AU - Barrera-Mendoza, Citlalli
AU - Jiménez-Vázquez, Hugo A.
AU - Vargas-Díaz, Elena
AU - Zepeda, L. Gerardo
PY - 2012/12
Y1 - 2012/12
N2 - The Weinreb amides 2a,b were prepared from the a,a-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded a-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.
AB - The Weinreb amides 2a,b were prepared from the a,a-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded a-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.
KW - A,a-dimethoxyacids
KW - A-ketoacetals
KW - Grignard reagents
KW - Salbutamol
KW - Weinreb amide
UR - http://www.scopus.com/inward/record.url?scp=84871556476&partnerID=8YFLogxK
U2 - 10.3390/molecules171213864
DO - 10.3390/molecules171213864
M3 - Artículo
C2 - 23174902
SN - 1420-3049
VL - 17
SP - 13864
EP - 13878
JO - Molecules
JF - Molecules
IS - 12
ER -