TY - JOUR
T1 - Effect on capillary permeability in rabbits of iridoids from Buddleia scordioides
AU - Perez Gutierrez, Rosa Martha
AU - Vargas Solis, Rosario
AU - Garcia Baez, Efren
AU - Martinez Martinez, Francisco
PY - 2006/7
Y1 - 2006/7
N2 - The methanol soluble fraction of the leaves of Buddleia scordioides after column chromatography resulted in the isolation of two known iridoid glucosides, catalpol and methylcatalpol. The structures were elucidated by extensive 1D-2D-NMR spectroscopy. The structure of methylcatalpol was confirmed by single-crystal x-ray diffraction. These compounds showed protective activity against increased (both chloroform and histamine) skin vascular permeability in rabbits. The protective effect was measured as the reduction in leakage of Evans blue. The results showed that the iridoids produced a significant inhibition of microvascular permeability. A comparison was made between the action of the iridoids and a known inhibitor of vascular permeability, troxerutin (50 mg/kg). Methylcatalpol and catalpol were found to be less effective than troxerutin.
AB - The methanol soluble fraction of the leaves of Buddleia scordioides after column chromatography resulted in the isolation of two known iridoid glucosides, catalpol and methylcatalpol. The structures were elucidated by extensive 1D-2D-NMR spectroscopy. The structure of methylcatalpol was confirmed by single-crystal x-ray diffraction. These compounds showed protective activity against increased (both chloroform and histamine) skin vascular permeability in rabbits. The protective effect was measured as the reduction in leakage of Evans blue. The results showed that the iridoids produced a significant inhibition of microvascular permeability. A comparison was made between the action of the iridoids and a known inhibitor of vascular permeability, troxerutin (50 mg/kg). Methylcatalpol and catalpol were found to be less effective than troxerutin.
KW - Buddleia scordioides
KW - Capillary permeability
KW - Catalpol
KW - Iridoid glucoside
KW - Methylcatalpol
UR - http://www.scopus.com/inward/record.url?scp=33745969889&partnerID=8YFLogxK
U2 - 10.1002/ptr.1893
DO - 10.1002/ptr.1893
M3 - Artículo
C2 - 16619344
SN - 0951-418X
VL - 20
SP - 542
EP - 545
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 7
ER -