TY - JOUR
T1 - Effect of early diabetes on the expression of alpha-1 adrenergic receptors in aorta and carotid arteries of wistar kyoto and spontaneously hypertensive rats
AU - Edith-Rodriguez, Jessica
AU - Resendiz-Albor, Aldo Arturo
AU - Arciniega-Martinez, Ivonne Maciel
AU - Campos-Rodriguez, Rafael
AU - Hong, Enrique
AU - Huang, Fengyang
AU - Villafaña, Santiago
N1 - Funding Information:
This work was supported by grants CONACYT CB-2012-01-183660 (Consejo Nacional de Ciencia y Tecnologia) and project SIP-IPN 20120786 (Secretaría de Investigación y Posgrado del Instituto Politecnico Nacional).
PY - 2013
Y1 - 2013
N2 - Hypertension and diabetes have been related to noradrenergic system impairment, especially to the response mediated by alpha-1 receptors. The aim of this work was to investigate possible changes in the expression of alpha-1 adrenergic receptors in aorta and carotid arteries of Wistar Kyoto and spontaneously hypertensive rats after 4 weeks of the onset of diabetes. Our results suggest that early diabetes modifies the expression of alpha-1 adrenergic receptors in aorta and carotid arteries of both WKY and SHR strains in a different way.
AB - Hypertension and diabetes have been related to noradrenergic system impairment, especially to the response mediated by alpha-1 receptors. The aim of this work was to investigate possible changes in the expression of alpha-1 adrenergic receptors in aorta and carotid arteries of Wistar Kyoto and spontaneously hypertensive rats after 4 weeks of the onset of diabetes. Our results suggest that early diabetes modifies the expression of alpha-1 adrenergic receptors in aorta and carotid arteries of both WKY and SHR strains in a different way.
KW - Adrenoceptors
KW - Alpha-1
KW - Aorta
KW - Carotid
KW - Diabetes type I
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=84884555026&partnerID=8YFLogxK
U2 - 10.3109/10641963.2012.739233
DO - 10.3109/10641963.2012.739233
M3 - Artículo
C2 - 23134281
SN - 1064-1963
VL - 35
SP - 389
EP - 395
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 6
ER -