TY - JOUR
T1 - Effect of botulinum toxin A on proliferation and apoptosis in the T47D breast cancer cell line
AU - Bandala, Cindy
AU - Perez-Santos, Jose Luis Martin
AU - Lara-Padilla, Eleazar
AU - Lopez, Ma Guadalupe Delgado
AU - Anaya-Ruiz, Maricruz
PY - 2013
Y1 - 2013
N2 - The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.
AB - The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.
KW - Apoptosis
KW - Botulinum toxin A
KW - Breast cancer
KW - Caspases
UR - http://www.scopus.com/inward/record.url?scp=84877643851&partnerID=8YFLogxK
U2 - 10.7314/APJCP.2013.14.2.891
DO - 10.7314/APJCP.2013.14.2.891
M3 - Artículo
SN - 1513-7368
VL - 14
SP - 891
EP - 894
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - 2
ER -