TY - JOUR
T1 - Effect of α-tocopherol on the metabolic control and oxidative stress in female type 2 diabetics
AU - Ble-Castillo, Jorge L.
AU - Carmona-Díaz, Elizabeth
AU - Méndez, José D.
AU - Larios-Medina, Francisco J.
AU - Medina-Santillán, Roberto
AU - Cleva-Villanueva, Guadalupe
AU - Díaz-Zagoya, Juan C.
N1 - Funding Information:
This study was supported by a grant from the Fondo de Fomento a la Investigación of the Instituto Mexicano del Seguro Social (IMSS, FP 2003/052). Jorge L. Blé Castillo is a member of the “Programa para el Mejoramiento del Profesorado de Educación Superior” (PROMEP-103.5/03/2178-UJATAB-148) and a doctoral fellow at the ESM, IPN, México D.F.
PY - 2005/7
Y1 - 2005/7
N2 - In this study we evaluate the effects of α-tocopherol on the metabolic control and oxidative stress in female patients with type 2 diabetes mellitus. Thirty-four female type 2 diabetics 40-70:years old up to 14:years with diabetes, under medical treatment, were randomly divided in two groups. One group received placebo (Control group, n = 21) and the other received α-tocopherol (800:IU/day, n = 13) during 6:weeks. Blood samples were collected at the beginning and at the end of the study to measure malondialdehyde production, glycated hemoglobin, selenium dependent-glutathione peroxidase, Cu,Zn-superoxide dismutase in erythrocytes and total antioxidant status, glucose, lipid and lipoproteins in serum. Erythrocyte malondialdehyde decreased and serum-total antioxidant status increased after α-tocopherol treatment (P < 0.0001). However, an unexpected increase on cholesterol levels and a reduced erythrocyte-Cu,Zn-superoxide dismutase activity was observed after α-tocopherol treatment. α-Tocopherol administration did not affect glucose, glycated hemoglobin, triacylglycerides, lipoprotein levels and serum malondialdehyde. A minor oxidative stress was observed in female type 2 diabetic patients after α-tocopherol treatment inferred from the reduced levels of erythrocyte malondialdehyde and the increased values of total antioxidant status. On the other hand, no beneficial changes were observed on glycemic control or lipid metabolism.
AB - In this study we evaluate the effects of α-tocopherol on the metabolic control and oxidative stress in female patients with type 2 diabetes mellitus. Thirty-four female type 2 diabetics 40-70:years old up to 14:years with diabetes, under medical treatment, were randomly divided in two groups. One group received placebo (Control group, n = 21) and the other received α-tocopherol (800:IU/day, n = 13) during 6:weeks. Blood samples were collected at the beginning and at the end of the study to measure malondialdehyde production, glycated hemoglobin, selenium dependent-glutathione peroxidase, Cu,Zn-superoxide dismutase in erythrocytes and total antioxidant status, glucose, lipid and lipoproteins in serum. Erythrocyte malondialdehyde decreased and serum-total antioxidant status increased after α-tocopherol treatment (P < 0.0001). However, an unexpected increase on cholesterol levels and a reduced erythrocyte-Cu,Zn-superoxide dismutase activity was observed after α-tocopherol treatment. α-Tocopherol administration did not affect glucose, glycated hemoglobin, triacylglycerides, lipoprotein levels and serum malondialdehyde. A minor oxidative stress was observed in female type 2 diabetic patients after α-tocopherol treatment inferred from the reduced levels of erythrocyte malondialdehyde and the increased values of total antioxidant status. On the other hand, no beneficial changes were observed on glycemic control or lipid metabolism.
KW - Alpha-tocopherol
KW - Antioxidant status
KW - Diabetes mellitus
KW - Lipoperoxidation
KW - Oxidative stress
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=23044469184&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2005.05.002
DO - 10.1016/j.biopha.2005.05.002
M3 - Artículo
SN - 0753-3322
VL - 59
SP - 290
EP - 295
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
IS - 6
ER -