Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet

Samantha Alejandra Real-Sandoval; Gustavo F. Gutiérrez-López; Aarón Domínguez-López; Norma Paniagua-Castro; Maria Monica Michicotl-Meneses; Maria Eugenia Jaramillo-Flores

doi:10.1016/j.jff.2020.103781

Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet

Samantha Alejandra Real-Sandoval, Gustavo F. Gutiérrez-López, Aarón Domínguez-López, Norma Paniagua-Castro, Maria Monica Michicotl-Meneses, Maria Eugenia Jaramillo-Flores

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

11 Citas (Scopus)

Resumen

Justicia spicigera is a plant used in traditional Mexican medicine to treat various diseases such as heart diseases and to improve blood circulation, with little scientific evidence. Therefore, this study evaluated the effect of the leaves of the plant and of kaempferitrin (main active ingredient), on biochemical, physiological, and inflammation markers related to obesity induced by a high-fat diet in male Wistar rats for eight weeks. The results indicated that J. spicigera powder has the ability to significantly decrease (p ≤ 0.05) the percentage of accumulated fat, and consequently, weight gain, as well as serum triglyceride concentrations. In addition, both J. spicigera powder and kaempferitrin generated transcriptional adaptations by negatively modulating the expression of pro-inflammatory genes such as Tlr4, Tnf-α, Nlrp3, Caspase-1, Il-18, Il-1β, Srebp-1c, Ppar-γ and Ucp2 and overexpressing Ppar-α.

Idioma original	Inglés
Número de artículo	103781
Publicación	Journal of Functional Foods
Volumen	65
DOI	https://doi.org/10.1016/j.jff.2020.103781
Estado	Publicada - feb. 2020

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1016/j.jff.2020.103781

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

Real-Sandoval, S. A., Gutiérrez-López, G. F., Domínguez-López, A., Paniagua-Castro, N., Michicotl-Meneses, M. M., & Jaramillo-Flores, M. E. (2020). Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet. Journal of Functional Foods, 65, Artículo 103781. https://doi.org/10.1016/j.jff.2020.103781

@article{d8a6d010ab4a4613bcf480235a3c9eb7,

title = "Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet",

abstract = "Justicia spicigera is a plant used in traditional Mexican medicine to treat various diseases such as heart diseases and to improve blood circulation, with little scientific evidence. Therefore, this study evaluated the effect of the leaves of the plant and of kaempferitrin (main active ingredient), on biochemical, physiological, and inflammation markers related to obesity induced by a high-fat diet in male Wistar rats for eight weeks. The results indicated that J. spicigera powder has the ability to significantly decrease (p ≤ 0.05) the percentage of accumulated fat, and consequently, weight gain, as well as serum triglyceride concentrations. In addition, both J. spicigera powder and kaempferitrin generated transcriptional adaptations by negatively modulating the expression of pro-inflammatory genes such as Tlr4, Tnf-α, Nlrp3, Caspase-1, Il-18, Il-1β, Srebp-1c, Ppar-γ and Ucp2 and overexpressing Ppar-α.",

keywords = "High-fat diet, Inflammation, Kaempferitrin, Liver, Obesity, Pro-inflamatory genes",

author = "Real-Sandoval, {Samantha Alejandra} and Guti{\'e}rrez-L{\'o}pez, {Gustavo F.} and Aar{\'o}n Dom{\'i}nguez-L{\'o}pez and Norma Paniagua-Castro and Michicotl-Meneses, {Maria Monica} and Jaramillo-Flores, {Maria Eugenia}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = feb,

doi = "10.1016/j.jff.2020.103781",

language = "Ingl{\'e}s",

volume = "65",

journal = "Journal of Functional Foods",

issn = "1756-4646",

}

Real-Sandoval, SA, Gutiérrez-López, GF , Domínguez-López, A , Paniagua-Castro, N, Michicotl-Meneses, MM & Jaramillo-Flores, ME 2020, 'Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet', Journal of Functional Foods, vol. 65, 103781. https://doi.org/10.1016/j.jff.2020.103781

Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet. / Real-Sandoval, Samantha Alejandra; Gutiérrez-López, Gustavo F.; Domínguez-López, Aarón et al.
En: Journal of Functional Foods, Vol. 65, 103781, 02.2020.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet

AU - Real-Sandoval, Samantha Alejandra

AU - Gutiérrez-López, Gustavo F.

AU - Domínguez-López, Aarón

AU - Paniagua-Castro, Norma

AU - Michicotl-Meneses, Maria Monica

AU - Jaramillo-Flores, Maria Eugenia

PY - 2020/2

Y1 - 2020/2

N2 - Justicia spicigera is a plant used in traditional Mexican medicine to treat various diseases such as heart diseases and to improve blood circulation, with little scientific evidence. Therefore, this study evaluated the effect of the leaves of the plant and of kaempferitrin (main active ingredient), on biochemical, physiological, and inflammation markers related to obesity induced by a high-fat diet in male Wistar rats for eight weeks. The results indicated that J. spicigera powder has the ability to significantly decrease (p ≤ 0.05) the percentage of accumulated fat, and consequently, weight gain, as well as serum triglyceride concentrations. In addition, both J. spicigera powder and kaempferitrin generated transcriptional adaptations by negatively modulating the expression of pro-inflammatory genes such as Tlr4, Tnf-α, Nlrp3, Caspase-1, Il-18, Il-1β, Srebp-1c, Ppar-γ and Ucp2 and overexpressing Ppar-α.

AB - Justicia spicigera is a plant used in traditional Mexican medicine to treat various diseases such as heart diseases and to improve blood circulation, with little scientific evidence. Therefore, this study evaluated the effect of the leaves of the plant and of kaempferitrin (main active ingredient), on biochemical, physiological, and inflammation markers related to obesity induced by a high-fat diet in male Wistar rats for eight weeks. The results indicated that J. spicigera powder has the ability to significantly decrease (p ≤ 0.05) the percentage of accumulated fat, and consequently, weight gain, as well as serum triglyceride concentrations. In addition, both J. spicigera powder and kaempferitrin generated transcriptional adaptations by negatively modulating the expression of pro-inflammatory genes such as Tlr4, Tnf-α, Nlrp3, Caspase-1, Il-18, Il-1β, Srebp-1c, Ppar-γ and Ucp2 and overexpressing Ppar-α.

KW - High-fat diet

KW - Inflammation

KW - Kaempferitrin

KW - Liver

KW - Obesity

KW - Pro-inflamatory genes

UR - http://www.scopus.com/inward/record.url?scp=85077711063&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2020.103781

DO - 10.1016/j.jff.2020.103781

M3 - Artículo

AN - SCOPUS:85077711063

SN - 1756-4646

VL - 65

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 103781

ER -

Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet

Resumen

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto