Distribución del tamaño de micropartículas lipídicas sólidas de ácido esteárico obtenidas por fusión-emulsificación

The encapsulation of drugs in microparticles is used actually as a drug transporter. The microparticles size is a key factor for its functioning. The application of different mathematical models is examined to describe the particle size. Stearic acid microparticles are obtained varying the surfactacts concentration and the emulsion dilution degree during the cooling phase. The log-normal distribution is the best, followed by the Weibull distribution. The surfactants stabilize suitably the microparticles and no differences were observed by changing their proportion. The homogenizer capability is the limiting factor to reduce the particle size. A decreasing particle size and a decreasing dispersion degree are observed as the proportion of the emulsion in the cooling mixture decreases.