TY - JOUR
T1 - Design and synthesis of N-(2-{[(2-hydroxy-naphtalen-1-yl)-phenyl-methyl]- amino}-ethyl)-3,4-dinitro-benzamide
AU - Figueroa-Valverde, Lauro
AU - Diaz-Cedillo, Francisco
AU - Garcia-Cervera, Elodia
AU - Pool-Gomez, Eduardo
AU - Lopez-Ramos, Maria
AU - Camacho-Luis, Abelardo
PY - 2013
Y1 - 2013
N2 - In this study, a new naphtol derivative was synthesized. The first stage, involved preparation of 1-[(2-Amino-ethylamino)-phenylmethyl]-naphthalen-2-ol (4) using a three-component system (β-naphtol [1], benzaldehyde [2], and ethylenediamine [3]), followed by the reaction of 4 with 3,5-dinitrobenzoic acid (5) to form N-(2-{[(2-Hydroxy-naphtalen-1-yl)-phenyl-methyl]-amino}-ethyl)-3,5- dinitro-benzamide (6) using a carbodiimide derivative or boric acid. The second stage, involves the synthesis of N-(2-aminoethyl)-3,5-dinitrobenzamide (7) by reaction of 5 with 3 using a carbodiimide derivative. Finally, the compound 6 was also synthetized using the three-component system (compound 7, benzaldehyde and â-naphtol). The structure of all compounds obtained was confirmed by elemental analysis, spectroscopy and spectrometry data. In conclusion, this method offers some advantages such as good yields, simple procedure, low cost, and ease of workup.
AB - In this study, a new naphtol derivative was synthesized. The first stage, involved preparation of 1-[(2-Amino-ethylamino)-phenylmethyl]-naphthalen-2-ol (4) using a three-component system (β-naphtol [1], benzaldehyde [2], and ethylenediamine [3]), followed by the reaction of 4 with 3,5-dinitrobenzoic acid (5) to form N-(2-{[(2-Hydroxy-naphtalen-1-yl)-phenyl-methyl]-amino}-ethyl)-3,5- dinitro-benzamide (6) using a carbodiimide derivative or boric acid. The second stage, involves the synthesis of N-(2-aminoethyl)-3,5-dinitrobenzamide (7) by reaction of 5 with 3 using a carbodiimide derivative. Finally, the compound 6 was also synthetized using the three-component system (compound 7, benzaldehyde and â-naphtol). The structure of all compounds obtained was confirmed by elemental analysis, spectroscopy and spectrometry data. In conclusion, this method offers some advantages such as good yields, simple procedure, low cost, and ease of workup.
KW - Boric acid
KW - Carbodiimide
KW - Naphtol derivative
UR - http://www.scopus.com/inward/record.url?scp=84877308783&partnerID=8YFLogxK
U2 - 10.13005/ojc/290103
DO - 10.13005/ojc/290103
M3 - Artículo
SN - 0970-020X
VL - 29
SP - 17
EP - 22
JO - Oriental Journal of Chemistry
JF - Oriental Journal of Chemistry
IS - 1
ER -