TY - JOUR
T1 - Design and synthesis of an aromatic-steroid derivative
AU - Figueroa-Valverde, L.
AU - Díaz-Cedillo, F.
AU - García-Cervera, E.
AU - Pool Gómez, E.
AU - Rosas-Nexticapa, M.
AU - López-Ramos, M.
AU - May-Gil, I.
PY - 2013
Y1 - 2013
N2 - In this study, an aromatic derivative was synthetized; the first stage involve the reaction of 3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,-14,-15,16,17- decahydro-6H-cyclopenta[a]-phenanthrene-2,4-dicarbaldehyde (compound 1) with ethylenediamine to form 2,4-Bis-[(2-amino-ethylimino)-methyl]-13-methyl-7,8,9, 11,12,13,14,15,16,17-decahydro-6H-cyclopenta[ a]phenanthrene-3,17-diol(3) using boric acid as catalyst. The second stage was achieved by the reaction of 3 with 4-hydroxybenzoic acid using carbodiimide derivative as catalyst to form the compound 5 (N-(2-{[3,17-Dihydroxy-4-({2-[1-(4-hydroxy-phenyl)vinylamino]-ethyl- imino}-methyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]- phenanthren-2-yl-methylene]-amino}-ethyl)-4-hydroxy-benzamide. The structure of compounds obtainedwas confirmed by elemental analysis, spectroscopy and spectrometry data. In conclusion, this method offers some advantages such as good yields, simple procedure, low cost, and ease of workup.
AB - In this study, an aromatic derivative was synthetized; the first stage involve the reaction of 3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,-14,-15,16,17- decahydro-6H-cyclopenta[a]-phenanthrene-2,4-dicarbaldehyde (compound 1) with ethylenediamine to form 2,4-Bis-[(2-amino-ethylimino)-methyl]-13-methyl-7,8,9, 11,12,13,14,15,16,17-decahydro-6H-cyclopenta[ a]phenanthrene-3,17-diol(3) using boric acid as catalyst. The second stage was achieved by the reaction of 3 with 4-hydroxybenzoic acid using carbodiimide derivative as catalyst to form the compound 5 (N-(2-{[3,17-Dihydroxy-4-({2-[1-(4-hydroxy-phenyl)vinylamino]-ethyl- imino}-methyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]- phenanthren-2-yl-methylene]-amino}-ethyl)-4-hydroxy-benzamide. The structure of compounds obtainedwas confirmed by elemental analysis, spectroscopy and spectrometry data. In conclusion, this method offers some advantages such as good yields, simple procedure, low cost, and ease of workup.
KW - Aromatic steroid derivatives
KW - Boric acid and catalyst
UR - http://www.scopus.com/inward/record.url?scp=84886006727&partnerID=8YFLogxK
U2 - 10.13005/ojc/290209
DO - 10.13005/ojc/290209
M3 - Artículo
SN - 0970-020X
VL - 29
SP - 465
EP - 468
JO - Oriental Journal of Chemistry
JF - Oriental Journal of Chemistry
IS - 2
ER -