TY - JOUR
T1 - Dendritic cells and Brucella spp. interaction
T2 - the sentinel host and the stealthy pathogen
AU - Avila-Calderón, Eric Daniel
AU - Flores-Romo, Leopoldo
AU - Sharon, Witonsky
AU - Donis-Maturano, Luis
AU - Becerril-García, Miguel Angel
AU - Arreola, Ma Guadalupe Aguilera
AU - Reynoso, Beatriz Arellano
AU - Güemes, Francisco Suarez
AU - Contreras-Rodríguez, Araceli
N1 - Publisher Copyright:
© 2019, Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - As dendritic cells (DCs) are among the first cells to encounter antigens, these cells trigger both innate and T cell responses, and are the most potent antigen-presenting cells. Brucella spp., which is an intracellular facultative and stealthy pathogen, is able to evade the bactericidal activities of professional phagocytes. Several studies have demonstrated that Brucella can survive and replicate intracellularly, thereby provoking impaired maturation of DCs. Therefore, the interaction between DCs and Brucella becomes an interesting model to study the immune response. In this review, we first will describe the most common techniques for DCs differentiation in vitro as well as general features of brucellosis. Then, the interaction of DCs and Brucella, including pathogen recognition, molecular mechanisms of bacterial pathogenesis, and intracellular trafficking of Brucella to subvert innate response, will be reviewed. Finally, we will debate diversity in immunological DC response and the controversial role of DC activation against Brucella infection.
AB - As dendritic cells (DCs) are among the first cells to encounter antigens, these cells trigger both innate and T cell responses, and are the most potent antigen-presenting cells. Brucella spp., which is an intracellular facultative and stealthy pathogen, is able to evade the bactericidal activities of professional phagocytes. Several studies have demonstrated that Brucella can survive and replicate intracellularly, thereby provoking impaired maturation of DCs. Therefore, the interaction between DCs and Brucella becomes an interesting model to study the immune response. In this review, we first will describe the most common techniques for DCs differentiation in vitro as well as general features of brucellosis. Then, the interaction of DCs and Brucella, including pathogen recognition, molecular mechanisms of bacterial pathogenesis, and intracellular trafficking of Brucella to subvert innate response, will be reviewed. Finally, we will debate diversity in immunological DC response and the controversial role of DC activation against Brucella infection.
UR - http://www.scopus.com/inward/record.url?scp=85061819116&partnerID=8YFLogxK
U2 - 10.1007/s12223-019-00691-6
DO - 10.1007/s12223-019-00691-6
M3 - Artículo de revisión
C2 - 30783994
SN - 0015-5632
VL - 65
JO - Folia Microbiologica
JF - Folia Microbiologica
IS - 1
ER -