TY - JOUR
T1 - Comparative pharmacokinetics of acetyl salicylic acid and its metabolites in children suffering from autoimmune diseases
AU - Olguín, Hugo Juárez
AU - Pérez, Janett Flores
AU - Asseff, Ismael Lares
AU - Abdalá, Arturo Loredo
AU - Rodríguez, Luis Carbajal
PY - 2004/1
Y1 - 2004/1
N2 - The aim of the present study was to compare the effect produced by juvenile rheumatoid arthritis (JRA) or rheumatic fever (RF) on the pharmacokinetics of acetyl salicylic acid (ASA) and its metabolites in children with autoimmune diseases (AD). Methods - A prospective, open labelled study was performed in 17 children with JRA and 17 with RF who received a single dose of 25 mg ASA/kg orally. The pharmacokinetics of ASA and its metabolites were determined. The blood and urine levels of each salicylate collected during 24h were measured by HPLC. A group of 15 healthy teenage volunteers was included as a control group. Results - The maximum plasma concentration, half-life time, area under the curve and the amount of salicylates excreted were statistically different between the JRA and the RF groups, as well as between the RF group and the controls, however, there were no significant differences between the JRA group and the controls. Conclusions - Dosage schemes must be adjusted for JRA patients, since the half life in these patients is longer than in RF patients. However, due to ample variability of pharmacokinetic parameters it is recommended that dose schemes are individualized on the type of autoimmune disease considered.
AB - The aim of the present study was to compare the effect produced by juvenile rheumatoid arthritis (JRA) or rheumatic fever (RF) on the pharmacokinetics of acetyl salicylic acid (ASA) and its metabolites in children with autoimmune diseases (AD). Methods - A prospective, open labelled study was performed in 17 children with JRA and 17 with RF who received a single dose of 25 mg ASA/kg orally. The pharmacokinetics of ASA and its metabolites were determined. The blood and urine levels of each salicylate collected during 24h were measured by HPLC. A group of 15 healthy teenage volunteers was included as a control group. Results - The maximum plasma concentration, half-life time, area under the curve and the amount of salicylates excreted were statistically different between the JRA and the RF groups, as well as between the RF group and the controls, however, there were no significant differences between the JRA group and the controls. Conclusions - Dosage schemes must be adjusted for JRA patients, since the half life in these patients is longer than in RF patients. However, due to ample variability of pharmacokinetic parameters it is recommended that dose schemes are individualized on the type of autoimmune disease considered.
KW - Aspirin
KW - Juvenile rheumatoid arthritis
KW - Metabolism
KW - Pharmacokinetics
KW - Rheumatic fever salicylates
UR - http://www.scopus.com/inward/record.url?scp=0742289924&partnerID=8YFLogxK
U2 - 10.1002/bdd.379
DO - 10.1002/bdd.379
M3 - Artículo
C2 - 14716747
AN - SCOPUS:0742289924
SN - 0142-2782
VL - 25
SP - 1
EP - 7
JO - Biopharmaceutics and Drug Disposition
JF - Biopharmaceutics and Drug Disposition
IS - 1
ER -