TY - JOUR
T1 - Comparación de la densidad capilar parafoveal entre sujetos sanos y diabéticos con y sin retinopatía
AU - Lima-Gómez, Virgilio
AU - Blanco-Hernández, Dulce Milagros Razo
AU - Somilleda-Ventura, Selma Alin
N1 - Publisher Copyright:
Copyright: © 2018 SecretarÍa de Salud.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Parafoveal capillary density changes have not been characterized in type 2 diabetics without retinopathy. Objective: To compare parafoveal capillary density between healthy subjects, and diabetics with and without retinopathy. Method: Observational, prospective, transversal and comparative study; subjects without diabetes (group 1), diabetics without retinopathy (group 2), with retinopathy (group 3) and with diabetic macular edema (group 4), without macular ischemia, were included. The study variable was parafoveal capillary density, and the predictor variables were the measures of the foveal avascular zone, retinal thickness and the group. The variables were compared between groups using Kruskal-Wallis and Spearman's Rho tests. Results: One hundred and forty eyes were evaluated; parafoveal capillary density was higher in group 1 than in the rest (p < 0.05). Area, perimeter and diameter of the foveal avascular zone were higher in group 3. A positive correlation existed a positive between parafoveal capillary density and central field thickness in groups 1, 2 and 3. Conclusion: Parafoveal capillary density decreases as diabetes-induced damage increase; a reduction may exist in diabetics without retinopathy and normal retinal thickness and foveal avascular zone are normal. The clinical impact of this finding requires further evaluation.
AB - Background: Parafoveal capillary density changes have not been characterized in type 2 diabetics without retinopathy. Objective: To compare parafoveal capillary density between healthy subjects, and diabetics with and without retinopathy. Method: Observational, prospective, transversal and comparative study; subjects without diabetes (group 1), diabetics without retinopathy (group 2), with retinopathy (group 3) and with diabetic macular edema (group 4), without macular ischemia, were included. The study variable was parafoveal capillary density, and the predictor variables were the measures of the foveal avascular zone, retinal thickness and the group. The variables were compared between groups using Kruskal-Wallis and Spearman's Rho tests. Results: One hundred and forty eyes were evaluated; parafoveal capillary density was higher in group 1 than in the rest (p < 0.05). Area, perimeter and diameter of the foveal avascular zone were higher in group 3. A positive correlation existed a positive between parafoveal capillary density and central field thickness in groups 1, 2 and 3. Conclusion: Parafoveal capillary density decreases as diabetes-induced damage increase; a reduction may exist in diabetics without retinopathy and normal retinal thickness and foveal avascular zone are normal. The clinical impact of this finding requires further evaluation.
KW - Densidad capilar parafoveal
KW - Diabetes
KW - Diabetic retinopathy
KW - Foveal avascular zone
KW - Optical coherence tomography
KW - Parafoveal capillary density
KW - Retinopatía diabética
KW - Tomografía de coherencia óptica
KW - Zona avascular foveal
UR - http://www.scopus.com/inward/record.url?scp=85058590436&partnerID=8YFLogxK
U2 - 10.24875/GMM.18004575
DO - 10.24875/GMM.18004575
M3 - Artículo
C2 - 30532093
AN - SCOPUS:85058590436
SN - 0016-3813
VL - 154
SP - S30-S35
JO - Gaceta Medica de Mexico
JF - Gaceta Medica de Mexico
ER -