TY - JOUR
T1 - Challenges in the Detection of SARS-CoV-2
T2 - Evolution of the Lateral Flow Immunoassay as a Valuable Tool for Viral Diagnosis
AU - Castrejón-Jiménez, Nayeli Shantal
AU - García-Pérez, Blanca Estela
AU - Reyes-Rodríguez, Nydia Edith
AU - Vega-Sánchez, Vicente
AU - Martínez-Juárez, Víctor Manuel
AU - Hernández-González, Juan Carlos
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/9
Y1 - 2022/9
N2 - SARS-CoV-2 is an emerging infectious disease of zoonotic origin that caused the coronavirus disease in late 2019 and triggered a pandemic that has severely affected human health and caused millions of deaths. Early and massive diagnosis of SARS-CoV-2 infected patients is the key to preventing the spread of the virus and controlling the outbreak. Lateral flow immunoassays (LFIA) are the simplest biosensors. These devices are clinical diagnostic tools that can detect various analytes, including viruses and antibodies, with high sensitivity and specificity. This review summarizes the advantages, limitations, and evolution of LFIA during the SARS-CoV-2 pandemic and the challenges of improving these diagnostic devices.
AB - SARS-CoV-2 is an emerging infectious disease of zoonotic origin that caused the coronavirus disease in late 2019 and triggered a pandemic that has severely affected human health and caused millions of deaths. Early and massive diagnosis of SARS-CoV-2 infected patients is the key to preventing the spread of the virus and controlling the outbreak. Lateral flow immunoassays (LFIA) are the simplest biosensors. These devices are clinical diagnostic tools that can detect various analytes, including viruses and antibodies, with high sensitivity and specificity. This review summarizes the advantages, limitations, and evolution of LFIA during the SARS-CoV-2 pandemic and the challenges of improving these diagnostic devices.
KW - COVID-19
KW - SARS-CoV-2
KW - antibodies
KW - biosensors
KW - diagnosis
KW - lateral flow immunoassay
UR - http://www.scopus.com/inward/record.url?scp=85138336471&partnerID=8YFLogxK
U2 - 10.3390/bios12090728
DO - 10.3390/bios12090728
M3 - Artículo de revisión
C2 - 36140114
AN - SCOPUS:85138336471
SN - 2079-6374
VL - 12
JO - Biosensors
JF - Biosensors
IS - 9
M1 - 728
ER -