TY - JOUR
T1 - Biomacromolecular localization in bacterial cells by the diffusion and capture mechanism
AU - Pérez Rodriguez, Miguel Angel
AU - Guo, Xianwu
N1 - Funding Information:
Acknowledgment This work was supported by Secretaría de Inves-tigación y Posgrado del Instituto Politécnico Nacional, México. (http://www.sip.ipn.mx/WPS/WCM/CONNECT/SIP/SIP/INICIO/ INDEX.HTM) (Grant numbers: 20080390 and 20091288) and by the Consejo Nacional de Ciencia y Tecnología-México (Convocatoria de Ciencias Básica 2011, grant number: 168541). The authors have declared that no competing interests exist. Xianwu Guo holds a scholarship from Comisión de Operación y Fomento de Actividades Académicas/Instituto Politécnico Nacional.
PY - 2013/9
Y1 - 2013/9
N2 - Subcellular localization of biomacromolecules (nucleotides and proteins) is the base for their proper function in bacterial cells. One model to explain the localization of biomacromolecules, particularly proteins, is "diffusion and capture". In this model, proteins are localized by diffusion through the cytoplasm or the membrane until binding to another protein or proteins that were already previously sequestered in cells. The use of fusions with fluorescent proteins to follow the fate of biomacromolecules has given new insight into the molecular localization mechanisms in living cells. Here, several proteins following a diffusion and capture mechanism to reach their proper location in the cells are presented. Some RNAs also seem to localize by this mechanism. It is an intrinsic feature that the information for molecular localization should exist in the sequences of protein itself. However, very little information has been available in this field to date.
AB - Subcellular localization of biomacromolecules (nucleotides and proteins) is the base for their proper function in bacterial cells. One model to explain the localization of biomacromolecules, particularly proteins, is "diffusion and capture". In this model, proteins are localized by diffusion through the cytoplasm or the membrane until binding to another protein or proteins that were already previously sequestered in cells. The use of fusions with fluorescent proteins to follow the fate of biomacromolecules has given new insight into the molecular localization mechanisms in living cells. Here, several proteins following a diffusion and capture mechanism to reach their proper location in the cells are presented. Some RNAs also seem to localize by this mechanism. It is an intrinsic feature that the information for molecular localization should exist in the sequences of protein itself. However, very little information has been available in this field to date.
KW - Capture
KW - Diffusion
KW - Localization
KW - Protein
UR - http://www.scopus.com/inward/record.url?scp=84884288487&partnerID=8YFLogxK
U2 - 10.1007/s13213-012-0596-3
DO - 10.1007/s13213-012-0596-3
M3 - Artículo de revisión
SN - 1590-4261
VL - 63
SP - 825
EP - 832
JO - Annals of Microbiology
JF - Annals of Microbiology
IS - 3
ER -