Resumen
An unexpected rearrangement of haemanthamine-type alkaloids in the presence of halogenating agents has been found. Rearranged compounds present the 5,11-methanomorphantridine framework characteristic of montanine-type alkaloids. These compounds are difficult to obtain because of their scarcity in natural sources and because the synthetic approaches developed so far require numerous steps. Vibrational circular dichroism (VCD) spectroscopy was used to determine the absolute configuration of one of the rearranged compounds. Several rearranged alkaloids showed antimalarial activity.
Idioma original | Inglés |
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Páginas (desde-hasta) | 1491-1494 |
Número de páginas | 4 |
Publicación | Organic Letters |
Volumen | 11 |
N.º | 7 |
DOI | |
Estado | Publicada - 2 abr. 2009 |
Publicado de forma externa | Sí |