Resumen
The hypoglycemic effects of hexane, chloroform and methanol extracts from fruits of Ferocactus latispinus and Ferocactus histrix were evaluated by oral administration to normoglucemic and streptozotocin-induced severe diabetic rats (SD). The anti-diabetic effect was examined by blood glucose, triglycerides, lipid peroxidation, total cholesterol levels in the serum, glycogen content of liver and skeletal muscles, superoxide dismutase (SOD) catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GSHPx) levels. The most active extracts were obtained with chloroform. Chloroform extracts from F. latispinus and F. histrix increased activities of SOD, GR, GSHPx and CAT, hepatic glycogen content, glucose-6-phosphatase (G6Pase) and the plasma insulin levels. They also, decreased glucokinase (GK) and TBAR (thiobarbituric acid assay). Of the two plants studied F. latispinus showed better antihyperglycemic and antihyperlipidemic effects that F. histrix. In conclusion F. latispinus and F. histrix possesses significant antihyperglycemic properties after 4 h after a single oral dose. It can also improve hyperlipidemia and hypoinsulinemia in streptozotocin-induced diabetic. These results demonstrated that F. latispinus and F. histrix typically used as a health food, has strong antidiabetic effects in vivo, thus, it may have beneficial properties in the prevention of diabetes.
Título traducido de la contribución | Attenuation of hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats by chloroform extract of fruits of Ferocactus latispinus and Ferocactus histrix |
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Idioma original | Español |
Páginas (desde-hasta) | 475-484 |
Número de páginas | 10 |
Publicación | Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas |
Volumen | 9 |
N.º | 6 |
Estado | Publicada - nov. 2010 |
Publicado de forma externa | Sí |
Palabras clave
- Antihyperglycemia
- Antihyperlipidemia
- Ferocactus histrix
- Ferocactus latispinus