TY - JOUR
T1 - Associations of SNPs located at candidate genes to bovine growth traits, prioritized with an interaction networks construction approach
AU - Paredes-Sánchez, Francisco Alejandro
AU - Sifuentes-Rincón, Ana María
AU - Segura Cabrera, Aldo
AU - García Pérez, Carlos Armando
AU - Parra Bracamonte, Gaspar Manuel
AU - Ambriz Morales, Pascuala
N1 - Publisher Copyright:
© 2015 Sánchez et al.
PY - 2015/7/22
Y1 - 2015/7/22
N2 - Background: For most domestic animal species, including bovines, it is difficult to identify causative genetic variants involved in economically relevant traits. The candidate gene approach is efficient because it investigates genes that are expected to be associated with the expression of a trait and defines whether the genetic variation present in a population is associated with phenotypic diversity. A potential limitation of this approach is the identification of candidates. This study used a bioinformatics approach to identify candidate genes via a search guided by a functional interaction network. Results: A functional interaction network tool, BosNet, was constructed for Bos taurus. Predictions for candidate genes were performed using the guilt-by-association principle in BosNet. Association analyses identified five novel markers within BosNet-prioritized genes that had significant effects on different growth traits in Charolais and Brahman cattle. Conclusions: BosNet is an excellent tool for the identification of single nucleotide polymorphisms that are potentially associated with complex traits.
AB - Background: For most domestic animal species, including bovines, it is difficult to identify causative genetic variants involved in economically relevant traits. The candidate gene approach is efficient because it investigates genes that are expected to be associated with the expression of a trait and defines whether the genetic variation present in a population is associated with phenotypic diversity. A potential limitation of this approach is the identification of candidates. This study used a bioinformatics approach to identify candidate genes via a search guided by a functional interaction network. Results: A functional interaction network tool, BosNet, was constructed for Bos taurus. Predictions for candidate genes were performed using the guilt-by-association principle in BosNet. Association analyses identified five novel markers within BosNet-prioritized genes that had significant effects on different growth traits in Charolais and Brahman cattle. Conclusions: BosNet is an excellent tool for the identification of single nucleotide polymorphisms that are potentially associated with complex traits.
KW - Beef cattle
KW - Candidate gene approach
KW - Economically relevant traits
KW - Genetic networks
UR - http://www.scopus.com/inward/record.url?scp=84937699996&partnerID=8YFLogxK
U2 - 10.1186/s12863-015-0247-3
DO - 10.1186/s12863-015-0247-3
M3 - Artículo
C2 - 26198337
SN - 1471-2156
VL - 16
JO - BMC Genetics
JF - BMC Genetics
IS - 1
M1 - 91
ER -